PXD032670 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Amelioration of Pathologic -Synuclein-Induced Parkinson’s Disease by Irisin |
Description | Physical activity is thought to provide clinical benefit in Parkinson’s diseas (PD). Irisin is a blood-brain barrier permeable exercise-induced polypeptide secreted by muscle that mediates, in part, the beneficial effects of exercise. Here we show that irisin prevents pathologic -synuclein (-syn) induced neurodegeneration in the -syn preformed fibril mouse model of sporadic PD. Intravenous delivery of adenoviral irisin in vivo after the stereotaxic intrastriatal injection of -syn pre-formed fibrils reduced the formation of pathologic -syn and prevented the loss of dopamine neurons and reductions in striatal dopamine. Irisin also reduced the -syn pre-formed fibril induced motor deficits as assessed by the pole test and grip strength test. Administration of recombinant irisin in primary cortical neurons prevented pathologic -syn toxicity. Tandem mass spectrometry and biochemical analysis revealed that irisin reduced pathologic -syn by enhancing endolysosomal degradation of pathologic -syn. Our findings highlight the potential for therapeutic disease modification of irisin in PD. |
HostingRepository | PRIDE |
AnnounceDate | 2023-11-14 |
AnnouncementXML | Submission_2023-11-14_08:14:33.245.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Jonathan Van Vranken |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | iodoacetamide derivatized residue |
Instrument | Orbitrap Eclipse |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-03-20 15:35:03 | ID requested | |
1 | 2022-10-14 16:36:39 | announced | |
⏵ 2 | 2023-11-14 08:14:35 | announced | 2023-11-14: Updated project metadata. |
Publication List
Kam TI, Park H, Chou SC, Van Vranken JG, Mittenb, ü, hler MJ, Kim H, A M, Choi YR, Biswas D, Wang J, Shin Y, Loder A, Karuppagounder SS, Wrann CD, Dawson VL, Spiegelman BM, Dawson TM, -synuclein-induced Parkinson's disease by irisin. Proc Natl Acad Sci U S A, 119(36):e2204835119(2022) [pubmed] |
Keyword List
submitter keyword: Irisin, alpha-synuclein, Neurodegeneration, Parkinson’s disease |
Contact List
Bruce Spiegelman |
contact affiliation | Dana Farber Cancer Institute, Boston, MA Harvard Medical School, Boston, MA |
contact email | bruce_spiegelman@dfci.harvard.edu |
lab head | |
Jonathan Van Vranken |
contact affiliation | Harvard Medical School |
contact email | van@hms.harvard.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD032670
- Label: PRIDE project
- Name: Amelioration of Pathologic -Synuclein-Induced Parkinson’s Disease by Irisin