PXD032667

PXD032667 is an original dataset announced via ProteomeXchange.

Title	Acute stress induces long-term metabolic, functional and structural remodeling of the heart
Description	Takotsubo syndrome is a stress-induced cardiomyopathy with symptoms comparable to those of acute coronary syndrome but without coronary obstruction. Initially considered spontaneously reversible, the reversibility of takotsubo was challenged by epidemiological studies showing high morbi-mortality in the long term. Here we explore comprehensively cardiac metabolism, structure and function after a single acute stress. We show that a single pharmacological stress is sufficient to recapitulate the clinical signs of ventricular dysfunction of takotsubo and their apparent reversibility. Interestingly, myocardial glucose metabolic remodeling during the acute phase was also present throughout the late recovery phases. Metabolic stunning where high glucose uptake is derived from glycolysis into alternative non-oxidative pathways such as the hexosamine biosynthetic and polyol pathways parallels with irreversible tissue and vascular remodeling. This study evidences that stress-induced diversion of glucose metabolism is the cause of deleterious structural and functional sequelae in takotsubo hearts.
HostingRepository	PRIDE
AnnounceDate	2023-06-28
AnnouncementXML	Submission_2023-06-28_04:30:36.844.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	FrançoisGUILLONNEAU
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2022-03-20 15:30:22	ID requested
⏵ 1	2023-06-28 04:30:37	announced

Dataset with its publication pending

submitter keyword: tims tof pro, mouse heart takotsubo model, label-free quantification,stress-induced cardiomyopathy

BertrandTavitian
contact affiliation	Plateforme d’Imageries du Vivant, Université Paris Cité, PARCC, INSERM, F-75006 Paris, France
contact email	bertrand.tavitian@inserm.fr
lab head
FrançoisGUILLONNEAU
contact affiliation	ICO Angers
contact email	francois.guillonneau@parisdescartes.fr
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/06/PXD032667

PRIDE project URI

• PRIDE
  1. PXD032667
     1. Label: PRIDE project
     2. Name: Acute stress induces long-term metabolic, functional and structural remodeling of the heart