PXD032660

PXD032660 is an original dataset announced via ProteomeXchange.

Title	Long-term aerobic exercise remodels the Proteome and Acetylome of mice skeletal muscle
Description	Exercise is an important strategy in the prevention and treatment of metabolic diseases, like diabetes and obesity. Alterations in the skeletal muscle proteome, including post-translational modifications, especially acetylation, regulate its metabolic adaptations to exercise. Here, we examined the effect of 6-week aerobic exercise and Scriptaid, a HDAC4/5 inhibitor, on the proteome and acetylome of skeletal muscle in mice. We find Scriptaid and exercise both induce acetylation modification changes of some proteins involved in metabolism, suggest that exercise improves metabolic health by regulating protein acetylation level.
HostingRepository	iProX
AnnounceDate	2022-04-06
AnnouncementXML	Submission_2022-09-29_01:24:55.663.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yanmei Niu
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2022-03-20 03:04:55	ID requested
1	2022-04-05 19:14:04	announced
⏵ 2	2022-09-29 01:24:56	announced	2022-09-29: Update publication information.

Liang D, Chen C, Huang S, Liu S, Fu L, Niu Y, Alterations of Lysine Acetylation Profile in Murine Skeletal Muscles Upon Exercise. Front Aging Neurosci, 14():859313(2022) [pubmed]

submitter keyword: aerobic exercise, skeletal muscle, proteome, acetylome, metabolism

Fu Li
contact affiliation	Tianjin Medical University
contact email	lifu@tmu.edu.cn
lab head
Yanmei Niu
contact affiliation	Tianjin Medical University
contact email	yanmei.niu@tmu.edu.cn
dataset submitter

iProX dataset URI