PXD032343

PXD032343 is an original dataset announced via ProteomeXchange.

Title	LC-MS/MS analysis for femoral vein of rat with deep venous thrombosis
Description	Secondary pathological changes after vascular injury include all the pathophysiology factors that cause thrombosis. However, this procedure is still complicated and volatile. Discovering new pathological changes associated with trauma and clarifying its mechanism is an important theoretical supplement to the pathology of thrombosis. Iron accumulation significantly accelerates thrombosis after vascular injury. The role of ferroptosis pathway induced by iron overtake in thrombosis was not elucidated. Here, we attempted to answer certain obscure question of the contribution of ferroptosis in DVT and explore its potential mechanism. A total 670 of DEPs involved 330 upregulated proteins and 340 downregulated proteins were identified in DVT group as compared with the control group. Otherwise, compared with DVT group, there were 842 DEPs consisting of 79 upregulated proteins and 763 downregulated proteins in DVTL (DVT+ liproxstatin-1) group. Differences between control, DVT and liproxstatin-1 treatment predominantly affected KEGG pathways of complement/coagulation cascades, glycolysis/ gluconeogenesis, ferroptosis and so on.
HostingRepository	iProX
AnnounceDate	2022-03-17
AnnouncementXML	Submission_2024-02-28_18:57:25.787.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Haotian Ma
SpeciesList	scientific name: Rattus norvegicus; NCBI TaxID: 10116;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2022-03-16 21:30:43	ID requested
1	2022-03-16 21:31:12	announced
⏵ 2	2024-02-28 18:57:26	announced	2024-02-29: Update information.

Ma H, Huang Y, Tian W, Liu J, Yan X, Ma L, Lai J, Endothelial transferrin receptor 1 contributes to thrombogenesis through cascade ferroptosis. Redox Biol, 70():103041(2024) [pubmed]

submitter keyword: Deep venous thrombosis, LC-MS/MS, Protein, Femoral vein

Jianghua Lai
contact affiliation	Xi'an Jiaotong University
contact email	laijh1011@mail.xjtu.edu.cn
lab head
Haotian Ma
contact affiliation	Xi'an Jiaotong University
contact email	forensicmht@stu.xjtu.edu.cn
dataset submitter

iProX dataset URI