PXD032306
PXD032306 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Src heterodimerically activates Lyn or Fyn to serve as targets for esophageal squamous cell carcinoma (ESCC) diagnosis and treatment |
| Description | we combined phosphoproteomics and several cellular and molecular biologic strategies to identify that Src specifically interacted with the members of Src-family kinases (SFKs), such as Fyn or Lyn to form heterodimers, and subsequently phosphorylate the tyrosine sites in SH2 and kinase domains, which critically contributed to the ESCC malignancy. |
| HostingRepository | iProX |
| AnnounceDate | 2022-03-15 |
| AnnouncementXML | Submission_2023-12-25_19:58:13.748.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Jing Zhang |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | phosphorylated residue |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2022-03-15 20:13:56 | ID requested | |
| 1 | 2023-05-04 19:03:00 | announced | |
| ⏵ 2 | 2023-12-25 19:58:14 | announced | 2023-12-26: Update information. |
Publication List
| Zhang J, Zhao D, Zhang L, Xiao Y, Wu Q, Wang Y, Chen J, Zhan Q, Src heterodimerically activates Lyn or Fyn to serve as targets for the diagnosis and treatment of esophageal squamous cell carcinoma. Sci China Life Sci, 66(6):1245-1263(2023) [pubmed] |
Keyword List
| submitter keyword: ESCC, SRC, heterodimer |
Contact List
| Qimin Zhan | |
|---|---|
| contact affiliation | Beijing Cancer Hospital |
| contact email | zhanqimin@bjmu.edu.cn |
| lab head | |
| Jing Zhang | |
| contact affiliation | Beijing Cancer Hospital |
| contact email | 15810815756@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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