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PXD032306

PXD032306 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleSrc heterodimerically activates Lyn or Fyn to serve as targets for esophageal squamous cell carcinoma (ESCC) diagnosis and treatment
Descriptionwe combined phosphoproteomics and several cellular and molecular biologic strategies to identify that Src specifically interacted with the members of Src-family kinases (SFKs), such as Fyn or Lyn to form heterodimers, and subsequently phosphorylate the tyrosine sites in SH2 and kinase domains, which critically contributed to the ESCC malignancy.
HostingRepositoryiProX
AnnounceDate2022-03-15
AnnouncementXMLSubmission_2023-12-25_19:58:13.748.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJing Zhang
SpeciesList scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationListphosphorylated residue
InstrumenttimsTOF Pro
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-03-15 20:13:56ID requested
12023-05-04 19:03:00announced
22023-12-25 19:58:14announced2023-12-26: Update information.
Publication List
Zhang J, Zhao D, Zhang L, Xiao Y, Wu Q, Wang Y, Chen J, Zhan Q, Src heterodimerically activates Lyn or Fyn to serve as targets for the diagnosis and treatment of esophageal squamous cell carcinoma. Sci China Life Sci, 66(6):1245-1263(2023) [pubmed]
Keyword List
submitter keyword: ESCC, SRC, heterodimer
Contact List
Qimin Zhan
contact affiliationBeijing Cancer Hospital
contact emailzhanqimin@bjmu.edu.cn
lab head
Jing Zhang
contact affiliationBeijing Cancer Hospital
contact email15810815756@163.com
dataset submitter
Full Dataset Link List
iProX dataset URI