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PXD032291

PXD032291 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleNoninvasive urinary protein signatures associated with colorectal cancer diagnosis and metastasis
DescriptionColorectal cancer is the 3rd commonly diagnosed cancer (10.2%) and 2nd cause of cancer death (9.2%) in all cancers.There will be estimated 1.8 million new colorectal cancer cases and 0.9 million colorectal cancer deaths in 20181. As the 5th incidence rates and mortality rates cancer in china, colorectal cancer incidence rates has increased from 1990 to 20112,3. CRC is concidered as a muti-step progress diseases4, patients with precursors lesions and early stage CRC can get great benefit from surgical treatment, colonoscope can detect visiable early dieases but not suitable for large-scale screening5, because of the poor sensitivity or specificity, blood carcinoembryonic antigen(CEA)6,7 and fecal blood testing(FOBT)8 provide limited help. There is no standard biomarker predicting CRC lymph node and liver metastasis4, although It’s very valuable for patients and docter before and after surgery9. Liver is the main site for colorectal cancer metastasis10, hepatic resection is the only treatment and successful for CRC-LM11, Unfortunately, over 50% of patients who get hepatic resection develop recurrences11, since then it’s hlepful to find biomarkers for monitoring CRC metastasis, blood CEA has been accepted as indicator of CRC progress12, in current study, we aim to explore a more convient and presion way for monitoring CRC metastasis.
HostingRepositoryiProX
AnnounceDate2022-03-15
AnnouncementXMLSubmission_2023-02-20_19:22:21.808.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterZongpan Jing
SpeciesList scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Fusion Lumos; TripleTOF 5600
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-03-15 00:54:47ID requested
12022-03-15 00:55:07announced
22023-02-20 19:22:22announced2023-02-21: Update information.
Publication List
Sun Y, Guo Z, Liu X, Yang L, Jing Z, Cai M, Zheng Z, Shao C, Zhang Y, Sun H, Wang L, Wang M, Li J, Tian L, Han Y, Zou S, Gao J, Zhao Y, Nan P, Xie X, Liu F, Zhou L, Sun W, Zhao X, Noninvasive urinary protein signatures associated with colorectal cancer diagnosis and metastasis. Nat Commun, 13(1):2757(2022) [pubmed]
Keyword List
submitter keyword: CRC urine PRM
Contact List
Xiaohang Zhao
contact affiliationState Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
contact emailzhaoxh@cicams.ac.cn
lab head
Zongpan Jing
contact affiliationState Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
contact email1129964712@qq.com
dataset submitter
Full Dataset Link List
iProX dataset URI