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PXD032288

PXD032288 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleHuman trabecular meshwork LC-MS/MS
DescriptionThe trabecular meshwork (TM) responsible for IOP homeostasis in the eye could sense the IOP fluctuations dynamically and adapt to the mechanical changes appropriately. Cationic mechanosensitive channels (CMCs) have been reported with critical roles in mediating the TM responding to many mechanical forces. However, the mechanism of how CMCs influence the TM cellular function in aqueous humor drainage and against mechanical damage is still elusive. Gene ontology enrichment analysis demonstrated that prohibition of CMCs significantly influenced the mechanical changes in the TM, such as store-operated calcium channel activity, microtubule cytoskeleton polarity, toll-like receptor signaling pathway, and neuron cell fate specification. Our results indicated that they might be the critical downstream signals of CMCs adapting to mechanical forces and mediating AH outflow.
HostingRepositoryiProX
AnnounceDate2022-03-14
AnnouncementXMLSubmission_2022-09-29_23:41:37.733.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterWei Zhu
SpeciesList scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-03-14 22:03:46ID requested
12022-03-14 22:04:02announced
22022-09-29 23:41:38announced2022-09-30: Update publication information.
Publication List
Chen S, Wang W, Cao Q, Wu S, Wang N, Ji L, Zhu W, Cationic Mechanosensitive Channels Mediate Trabecular Meshwork Responses to Cyclic Mechanical Stretch. Front Pharmacol, 13():881286(2022) [pubmed]
Keyword List
submitter keyword: Human, Trabecular meshwork, Stretch, Cationic mechanosensitive channels, LC-MS/MS
Contact List
Wei Zhu
contact affiliationSchool of Pharmacy, Qingdao University
contact emailwzhu@qdu.edu.cn
lab head
Wei Zhu
contact affiliationSchool of Pharmacy, Qingdao University
contact emailwzhu@qdu.edu.cn
dataset submitter
Full Dataset Link List
iProX dataset URI