PXD032288
PXD032288 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Human trabecular meshwork LC-MS/MS |
Description | The trabecular meshwork (TM) responsible for IOP homeostasis in the eye could sense the IOP fluctuations dynamically and adapt to the mechanical changes appropriately. Cationic mechanosensitive channels (CMCs) have been reported with critical roles in mediating the TM responding to many mechanical forces. However, the mechanism of how CMCs influence the TM cellular function in aqueous humor drainage and against mechanical damage is still elusive. Gene ontology enrichment analysis demonstrated that prohibition of CMCs significantly influenced the mechanical changes in the TM, such as store-operated calcium channel activity, microtubule cytoskeleton polarity, toll-like receptor signaling pathway, and neuron cell fate specification. Our results indicated that they might be the critical downstream signals of CMCs adapting to mechanical forces and mediating AH outflow. |
HostingRepository | iProX |
AnnounceDate | 2022-03-14 |
AnnouncementXML | Submission_2022-09-29_23:41:37.733.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Wei Zhu |
SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2022-03-14 22:03:46 | ID requested | |
1 | 2022-03-14 22:04:02 | announced | |
⏵ 2 | 2022-09-29 23:41:38 | announced | 2022-09-30: Update publication information. |
Publication List
Chen S, Wang W, Cao Q, Wu S, Wang N, Ji L, Zhu W, Cationic Mechanosensitive Channels Mediate Trabecular Meshwork Responses to Cyclic Mechanical Stretch. Front Pharmacol, 13():881286(2022) [pubmed] |
Keyword List
submitter keyword: Human, Trabecular meshwork, Stretch, Cationic mechanosensitive channels, LC-MS/MS |
Contact List
Wei Zhu | |
---|---|
contact affiliation | School of Pharmacy, Qingdao University |
contact email | wzhu@qdu.edu.cn |
lab head | |
Wei Zhu | |
contact affiliation | School of Pharmacy, Qingdao University |
contact email | wzhu@qdu.edu.cn |
dataset submitter |
Full Dataset Link List
iProX dataset URI |