PXD032288

PXD032288 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Human trabecular meshwork LC-MS/MS
Description	The trabecular meshwork (TM) responsible for IOP homeostasis in the eye could sense the IOP fluctuations dynamically and adapt to the mechanical changes appropriately. Cationic mechanosensitive channels (CMCs) have been reported with critical roles in mediating the TM responding to many mechanical forces. However, the mechanism of how CMCs influence the TM cellular function in aqueous humor drainage and against mechanical damage is still elusive. Gene ontology enrichment analysis demonstrated that prohibition of CMCs significantly influenced the mechanical changes in the TM, such as store-operated calcium channel activity, microtubule cytoskeleton polarity, toll-like receptor signaling pathway, and neuron cell fate specification. Our results indicated that they might be the critical downstream signals of CMCs adapting to mechanical forces and mediating AH outflow.
HostingRepository	iProX
AnnounceDate	2022-03-14
AnnouncementXML	Submission_2022-09-29_23:41:37.733.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Wei Zhu
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2022-03-14 22:03:46	ID requested
1	2022-03-14 22:04:02	announced
⏵ 2	2022-09-29 23:41:38	announced	2022-09-30: Update publication information.

Publication List

Chen S, Wang W, Cao Q, Wu S, Wang N, Ji L, Zhu W, Cationic Mechanosensitive Channels Mediate Trabecular Meshwork Responses to Cyclic Mechanical Stretch. Front Pharmacol, 13():881286(2022) [pubmed]

Chen S, Wang W, Cao Q, Wu S, Wang N, Ji L, Zhu W, Cationic Mechanosensitive Channels Mediate Trabecular Meshwork Responses to Cyclic Mechanical Stretch. Front Pharmacol, 13():881286(2022) [pubmed]

Keyword List

submitter keyword: Human, Trabecular meshwork, Stretch, Cationic mechanosensitive channels, LC-MS/MS

submitter keyword: Human, Trabecular meshwork, Stretch, Cationic mechanosensitive channels, LC-MS/MS

Contact List

Wei Zhu
contact affiliation	School of Pharmacy, Qingdao University
contact email	wzhu@qdu.edu.cn
lab head
Wei Zhu
contact affiliation	School of Pharmacy, Qingdao University
contact email	wzhu@qdu.edu.cn
dataset submitter

Full Dataset Link List

iProX dataset URI

iProX dataset URI