PXD032189
PXD032189 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Integrated Network Pharmacology and Proteomics to Reveal the Molecular Therapeutic Effects of Buyang Huanwu Decoction on Ischemic Stroke |
| Description | Ischemic stroke (IS), as a common cerebrovascular disease, is characterized by high disability, mortality, recurrence, and complications. Studies have shown that Buyang Huanwu Decoction (BHD) can impact the treatment of acute cerebral infarction, subsequent recovery, and sequelae. However, the mechanism of action of BHD in IS treatment remains unclear. To this end, we applied a combined network pharmacology and proteomics approach to investigate the mechanism of action of BHD. First, the chemical components of BHD were revealed by ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-QTOFMS/MS). The molecular mechanism of BHD in treating IS was preliminarily elucidated through a network pharmacological approach. Subsequently, proteomic studies were used to explore the biomarkers of BHD in IS treatment |
| HostingRepository | iProX |
| AnnounceDate | 2022-03-11 |
| AnnouncementXML | Submission_2022-03-10_19:07:20.146.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Yingying He |
| SpeciesList | scientific name: Rattus rattus; NCBI TaxID: 10117; |
| ModificationList | TMT6plex reporter fragment |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2022-03-10 19:07:04 | ID requested | |
| ⏵ 1 | 2022-03-10 19:07:21 | announced |
Publication List
| He Y, Zheng H, Zhong L, Zhong N, Wen G, Wang L, Zhang Y, Identification of Active Ingredients of Huangqi Guizhi Wuwu Decoction for Promoting Nerve Function Recovery After Ischemic Stroke Using HT22 Live-Cell-Based Affinity Chromatography Combined with HPLC-MS/MS. Drug Des Devel Ther, 15():5165-5178(2021) [pubmed] |
Keyword List
| submitter keyword: Proteomics, Buyang Huanwu Decoction, Ischemic Stroke |
Contact List
| Lisheng Wang | |
|---|---|
| contact affiliation | Guangzhou University of Chinese Medicine |
| contact email | wlis68@126.com |
| lab head | |
| Yingying He | |
| contact affiliation | Guangzhou University of Chinese Medicine |
| contact email | 13189086632@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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