PXD032179

PXD032179 is an original dataset announced via ProteomeXchange.

Title	Plasma proteome profiling combined with clinical and genetic features reveals pathophysiological characteristics of β-thalassemia
Description	The phenotype of β-thalassemia underlies multigene interactions, making clinical stratification complicated. An increasing number of genetic modifiers affecting the disease severity have been identified, but are still unable to meet the demand of precision diagnosis. Here, we systematically conducted a comparative plasma proteomic profiling on β-thalassemia patients and healthy controls. Plasma samples from 20 TM patients, 20 TI patients, and 20 healthy controls were used for the quantitative proteomic analysis. Among 246 dysregulated proteins, 13 core protein signatures with excellent biomarker potential are proposed. The combination of proteome and patients' clinical data revealed patients with codons 41/42 -TTCT mutations have an elevated risk of higher iron burden, dysplasia, and osteoporosis than patients with other genotypes. Notably, 85 proteins correlating to fetal hemoglobin (Hb F) were identified, among which the abundance of 27 proteins may affect the transfusion burden in β-thalassemia patients. The current study thus provides protein signatures as potential diagnostic biomarkers or therapeutic clues for β-thalassemia.
HostingRepository	iProX
AnnounceDate	2022-03-10
AnnouncementXML	Submission_2022-04-28_00:16:02.334.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Na Li
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue; methionine oxidation with neutral loss of 64 Da; TMT6plex reporter fragment
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2022-03-09 20:41:55	ID requested
1	2022-03-09 20:42:04	announced
⏵ 2	2022-04-28 00:16:03	announced	2022-04-28: Update publication information.

Li N, An P, Wang J, Zhang T, Qing X, Wu B, Sun L, Ding X, Niu L, Xie Z, Zhang M, Guo X, Chen X, Cai T, Luo J, Wang F, Yang F, -thalassemia. iScience, 25(4):104091(2022) [pubmed]

submitter keyword: β-thalassemia, human plasma proteome, clinical data, biomarker, codons 41/42 -TTCT, fetal hemoglobin

Fuquan Yang
contact affiliation	Institute of Biophysics, Chinese Academy of Sciences
contact email	fqyang@ibp.ac.cn
lab head
Na Li
contact affiliation	Institute of Biophysics, Chinese Academy of Sciences
contact email	lina@ibp.ac.cn
dataset submitter

iProX dataset URI