PXD032148

PXD032148 is an original dataset announced via ProteomeXchange.

Title	Sarcoptes scabiei somatic proteomes
Description	Presently, there is a dearth of proteomic data for parasitic mites and their relationship with the host animals. Here, using a high throughput LC-MS/MS-based approach, we undertook the first comprehensive, large-scale proteomic investigation of egg and adult female stages of the scabies mite, Sarcoptes scabiei – one of the most important parasitic mites of humans and other animals worldwide. In total, 1,761 S. scabiei proteins were identified and quantified with high confidence. Bioinformatic analyses revealed differentially expressed proteins to be involved predominantly in biological pathways or processes including genetic information processing, energy (oxidative phosphorylation), nucleotide, amino acid, carbohydrate and/or lipid metabolism, and some adaptive processes. These proteomic data set will enable future molecular, biochemical and physiological investigations of early developmental stages of S. scabiei and the discovery of novel interventions targeting the egg stage, given its non-susceptibility to current acaricidal treatments.
HostingRepository	PRIDE
AnnounceDate	2022-11-11
AnnouncementXML	Submission_2022-11-10_20:13:45.690.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	TaoWang
SpeciesList	scientific name: Sarcoptes scabiei; NCBI TaxID: 52283;
ModificationList	methylthiolated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2022-03-09 02:07:44	ID requested
⏵ 1	2022-11-10 20:13:46	announced

Dataset with its publication pending

submitter keyword: Proteomes

Sarcoptes scabiei

parasitic mite

egg and adult stages

scabies

human

Robin BeatGasser
contact affiliation	Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Australia
contact email	robinbg@unimelb.edu.au
lab head
TaoWang
contact affiliation	The University of Melbourne
contact email	tao.wang1@unimelb.edu.au
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/11/PXD032148

PRIDE project URI

• PRIDE
  1. PXD032148
     1. Label: PRIDE project
     2. Name: Sarcoptes scabiei somatic proteomes