PXD032127

PXD032127 is an original dataset announced via ProteomeXchange.

Title	Proteomic and metabolomic signatures associated with the immune response in healthy individuals immunized with an inactivated SARS-CoV-2 vaccine
Description	CoronaVac (Sinovac), an inactivated vaccine for SARS-CoV-2, has been widely used for immunization. However, analysis of the underlying molecular mechanisms driving CoronaVac-induced immunity is still limited. Here, we applied a systems biology approach to understand the mechanisms behind the adaptive immune response to CoronaVac in a cohort of 50 volunteers immunized with 2 doses of CoronaVac. Vaccination with CoronaVac led to an integrated immune response that included several effector arms of the adaptive immune system including specific IgM/IgG, humoral response and other immune response, as well as the innate immune system as shown by complement activation. Metabolites associated with immunity were also identified implicating the role of metabolites in the humoral response, complement activation and other immune response. Networks associated with the TCA cycle and amino acids metabolic pathways, such as phenylalanine metabolism, phenylalanine, tyrosine and tryptophan biosynthesis, and glycine, serine and threonine metabolism were tightly coupled with immunity. Critically, we constructed a multifactorial response network (MRN) to analyze the underlying interactions and compared the signatures affected by CoronaVac immunization and SARS-CoV-2 infection to further identify immune signatures and related metabolic pathways altered by CoronaVac immunization. These results help us to understand the host response to vaccination of CoronaVac and highlight the utility of a systems biology approach in defining molecular correlates of protection to vaccination.
HostingRepository	iProX
AnnounceDate	2022-03-09
AnnouncementXML	Submission_2022-06-21_05:16:01.888.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yi Wang
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2022-03-08 18:50:53	ID requested
1	2022-03-08 18:51:06	announced
⏵ 2	2022-06-21 05:16:02	announced	2022-06-21: Update publication information.

Wang Y, Wang X, Luu LDW, Chen S, Jin F, Wang S, Huang X, Wang L, Zhou X, Chen X, Cui X, Li J, Tai J, Zhu X, Proteomic and Metabolomic Signatures Associated With the Immune Response in Healthy Individuals Immunized With an Inactivated SARS-CoV-2 Vaccine. Front Immunol, 13():848961(2022) [pubmed]

submitter keyword: COVID-19, SARS-CoV-2, CoronaVac, Proteomics, Metabolomics

Immune response.

Yi Wang
contact affiliation	Capital Institute of Pediatrics
contact email	wildwolf0101@163.com
lab head
Yi Wang
contact affiliation	Capital Institute of Pediatrics
contact email	wildwolf0101@163.com
dataset submitter

iProX dataset URI