PXD032101

PXD032101 is an original dataset announced via ProteomeXchange.

Title	Extracellular release of two peptidases dominates generation of the quorum sensing signal in Trypanosoma brucei
Description	Trypanosomes causing African sleeping sickness use quorum sensing to control the production of transmission-competent stumpy forms in their mammalian hosts. This density-dependent process is signalled by the release of parasite peptidases whose action generates oligopeptides that stimulate the signal transduction pathway leading to stumpy formation. Using mass spectrometry analysis, we have characterised the peptidases released by Trypanosoma brucei brucei.
HostingRepository	PRIDE
AnnounceDate	2022-08-12
AnnouncementXML	Submission_2022-08-12_00:09:09.578.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD032101
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Keith Matthews
SpeciesList	scientific name: Trypanosoma brucei; NCBI TaxID: 5691;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2022-03-07 03:51:05	ID requested
⏵ 1	2022-08-12 00:09:10	announced

Tettey MD, Rojas F, Matthews KR, Extracellular release of two peptidases dominates generation of the trypanosome quorum-sensing signal. Nat Commun, 13(1):3322(2022) [pubmed]

submitter keyword: Trypanosoma brucei, quorum sensing, stumpy forms, transmission, peptidase

Professor Keith R. Matthews
contact affiliation	University of Edinburgh Institute of Immunology and Infection Research
contact email	keith.matthews@ed.ac.uk
lab head
Keith Matthews
contact affiliation	University of Edinburgh
contact email	keith.matthews@ed.ac.uk
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD032101
     1. Label: PRIDE project
     2. Name: Extracellular release of two peptidases dominates generation of the quorum sensing signal in Trypanosoma brucei