Updated project metadata. Import of ferrous iron (Fe2+) via the plasma membrane ZIP transporter IRON-REGULATED TRANSPORTER1 (IRT1) bears the risk of oxidative damage and lipid peroxidation. The plasma membrane-associated SEC14-like lipid transfer protein PATL2 interacts with the large cytosolic loop and variable region of IRT1 (IRT1vr). PATL2 affects Fe reduction and reactive oxygen species-related responses in roots and alleviates lipid peroxidation upon Fe acquisition. PATL2 binds α-tocopherol, an antioxidant of the vitamin E group.