PXD032076

PXD032076 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Identification of carcinogenesis and tumor progression processes in pancreatic ductal adenocarcinoma using high-throughput proteomics
Description	Pancreatic adenocarcinoma (PDAC) is an aggressive disease with an overall 5 year-survival rate of just 5%. A better understanding of both the carcinogenesis processes and the mechanisms of progression of PDAC disease is mandatory. For this, proteomics data from FFPE samples of 173 primary tumor, normal tissue, preneoplastic lesions (PanIN), or lymph node metastases were analyzed from a Systems Biology perspective. Protein expression data was analyzed using probabilistic graphical models, allowing functional characterization. Functional node activities were calculated as the mean of expression of those proteins related to the main function of each node. Comparisons between groups were done using linear mixed models.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:37:45.262.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Antje Dittmann
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2022-03-05 05:24:29	ID requested
1	2022-06-21 06:21:12	announced
⏵ 2	2024-10-22 05:37:46	announced	2024-10-22: Updated project metadata.

Publication List

10.3390/cancers14102414;
Trilla-Fuertes L, G, á, mez-Pozo A, Lumbreras-Herrera MI, L, ó, pez-Vacas R, Heredia-Soto V, Ghanem I, L, ó, pez-Camacho E, Zapater-Moros A, Miguel M, Pe, ñ, a-Burgos EM, Palacios E, De Uribe M, Guerra L, Dittmann A, Mendiola M, Fresno Vara J Á, Feliu J, Identification of Carcinogenesis and Tumor Progression Processes in Pancreatic Ductal Adenocarcinoma Using High-Throughput Proteomics. Cancers (Basel), 14(10):(2022) [pubmed]

10.3390/cancers14102414;

Trilla-Fuertes L, G, á, mez-Pozo A, Lumbreras-Herrera MI, L, ó, pez-Vacas R, Heredia-Soto V, Ghanem I, L, ó, pez-Camacho E, Zapater-Moros A, Miguel M, Pe, ñ, a-Burgos EM, Palacios E, De Uribe M, Guerra L, Dittmann A, Mendiola M, Fresno Vara J Á, Feliu J, Identification of Carcinogenesis and Tumor Progression Processes in Pancreatic Ductal Adenocarcinoma Using High-Throughput Proteomics. Cancers (Basel), 14(10):(2022) [pubmed]

Keyword List

ProteomeXchange project tag: EPIC-XS
submitter keyword: FFPE, pancreatic ductal adenocarcinoma,Huamn, linear mixed model, lymph node, PDAC, metastasis

ProteomeXchange project tag: EPIC-XS

submitter keyword: FFPE, pancreatic ductal adenocarcinoma,Huamn, linear mixed model, lymph node, PDAC, metastasis

Contact List

Jamie Feliu
contact affiliation	Medical Oncology Service, Hospital Universitario La Paz-IdiPAZ, Madrid
contact email	jaimefeliu@hotmail.com
lab head
Antje Dittmann
contact affiliation	UZH
contact email	antje.dittmann@gmail.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/06/PXD032076
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/06/PXD032076

PRIDE project URI

Repository Record List

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