PXD032068

PXD032068 is an original dataset announced via ProteomeXchange.

Title	Identifying interaction proteins of METTL16 using co immunoprecipitation and mass spectroscopy
Description	METTL16 has recently been identified as an RNA methyltransferase that installs m6A marks on a few transcripts. But its function in cytosol remains unclear. Puromycin-labelling and renilla luciferase assay revealed that METTL16 can promote translation efficiency in an m6A-independent manner. To explore the mechanism, we performed co-immunoprecipitation using METTL16 antibody and mass spectroscopy to identify its interaction proteins. Moreover, we find that METTL16 is essential for tumorigenesis of non-small cell lung cancer.
HostingRepository	PRIDE
AnnounceDate	2024-08-03
AnnouncementXML	Submission_2024-08-02_19:55:02.824.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xue Mi
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2022-03-05 04:57:40	ID requested
⏵ 1	2024-08-02 19:55:03	announced

10.1016/J.CELREP.2023.112150;

submitter keyword: NSCLC,IP-MS, A549,METTL16

Jun Zhou
contact affiliation	School of Life Science and Technology, China Pharmaceutical University
contact email	jz572@cpu.edu.cn
lab head
Xue Mi
contact affiliation	School of Life Science and Technology, China Pharmaceutical University
contact email	3320031536@stu.cpu.edu.cn
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/08/PXD032068

PRIDE project URI

• PRIDE
  1. PXD032068
     1. Label: PRIDE project
     2. Name: Identifying interaction proteins of METTL16 using co immunoprecipitation and mass spectroscopy