PXD032044

PXD032044 is an original dataset announced via ProteomeXchange.

Title	Characterization of the skeletal muscle proteome in under-nourished old rats
Description	Therefore, undernutrition is common in the elderly where its prevalence varies from 4 to 10% at home, from 15 to 30% in care homes and reaches 30 to 70% in hospitals de-pending on the diagnostic criteria used [10]. Most of all, aging impairs the ability to adapt to undernutrition leading to severe loss of body weight and muscle [11-14]. In particular, old rats exhibit defective adaptation to long-term 50% dietary restriction initiated at an advanced age, resulting in dramatic body weight loss and deregulation of protein metabolism in terms of nitrogen balance and protein content, especially at skeletal muscle level [12]. Therefore, in elderly patients, undernutrition exacerbates the state of frailty and dependence, greatly increasing the risk of morbidity and mortality [15]. This is even more critical that the world aging population is growing up. Accord-ing to United Nations statistics on the demographic trend in aging population, the proportion of persons aged 65 or over in the world is projected to reach nearly 16% in 2050, compared to 9% in 2019 [16]. Specific studies are needed to better understand the undernutrition-induced skeletal muscle alterations in order to identify new therapeu-tic targets and prevent sarcopenia in the old population
HostingRepository	PRIDE
AnnounceDate	2022-06-09
AnnouncementXML	Submission_2022-06-09_09:08:57.185.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	christophe Chambon
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationList	amidated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2022-03-03 12:04:15	ID requested
⏵ 1	2022-06-09 09:08:58	announced

Barb, é C, Salles J, Chambon C, Giraudet C, Sanchez P, Patrac V, Denis P, Boirie Y, Walrand S, Gueugneau M, Characterization of the Skeletal Muscle Proteome in Undernourished Old Rats. Int J Mol Sci, 23(9):(2022) [pubmed]

ProteomeXchange project tag: Skeletal Muscle Proteome (B/D-HPP), Biology/Disease-Driven Human Proteome Project (B/D-HPP), Human Proteome Project

submitter keyword: skeletal muscle

aging

sarcopenia

undernutrition

proteome

PFEM composante proteomique
contact affiliation	INRAE Theix-PFEM-UR QUAPA
contact email	christophe.chambon@inrae.fr
lab head
christophe Chambon
contact affiliation	INRAE
contact email	christophe.chambon@inrae.fr
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/06/PXD032044

PRIDE project URI

• PRIDE
  1. PXD032044
     1. Label: PRIDE project
     2. Name: Characterization of the skeletal muscle proteome in under-nourished old rats