PXD032039

PXD032039 is an original dataset announced via ProteomeXchange.

Title	DUSP1/6-mediated phosphorylation signaling events in CLL
Description	Despite strong evidence of a significant role of MAPK signaling in chronic lymphocytic leukemia (CLL), phosphatase development and progression, this pathway is up to date not targeted in CLL therapy and available BRAF and MEK inhibitors are not efficient in reducing tumor progression. In this study, we evaluated the effects of targeted hyperactivation of the MAPK signaling pathway in CLL.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_09:05:44.228.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Piero Giansanti
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2022-03-03 11:55:49	ID requested
1	2023-10-09 03:57:58	announced
⏵ 2	2023-11-14 09:05:52	announced	2023-11-14: Updated project metadata.

Ecker V, Brandmeier L, Stumpf M, Giansanti P, Moreira AV, Pfeuffer L, Fens MHAM, Lu J, Kuster B, Engleitner T, Heidegger S, Rad R, Ringshausen I, Zenz T, Wendtner CM, M, ü, schen M, Jellusova J, Ruland J, Buchner M, Negative feedback regulation of MAPK signaling is an important driver of chronic lymphocytic leukemia progression. Cell Rep, 42(10):113017(2023) [pubmed]

submitter keyword: phosphoproteomics, DUSP1, DUSP6, apoptosis, DNA damage response, chronic lymphocytic leukemia

Bernhard Kuster
contact affiliation	Chair of Proteomics and Bioanalytics, Technical University of Munich, Freising, Germany
contact email	kuster@tum.de
lab head
Piero Giansanti
contact affiliation	Technical University of Munich
contact email	piero.giansanti@tum.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/10/PXD032039

PRIDE project URI

• PRIDE
  1. PXD032039
     1. Label: PRIDE project
     2. Name: DUSP1/6-mediated phosphorylation signaling events in CLL