PXD032002 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Characterization of the Chemotherapy-treated PyMT Matrisome |
Description | Cytotoxic chemotherapy is used to treat many thousands of patients across many cancer types annually. Recent studies have demonstrated that chemotherapy causes systemic response that can be exploited to promote cancer cell survival and dissemination, termed “chemotherapy-induced metastasis. However, there have been no studies investigating how chemotherapy alters the extracellular matrix of breast tumors, or if those changes might help to support metastatic dissemination. Here, we report the first characterization of the chemotherapy-treated breast cancer matrisome using the MMTV-PyMT transgenic mouse model of breast cancer. We identify distinct changes induced by different cytotoxic chemotherapies. In particular, we identify collagen IV as significantly associated with taxane-based chemotherapy treatment. Biological validation confirmed collagen IV as chemotherapy-associated and identified collagen IV-driven Src and FAK signaling as important mediators of invasion in the post-chemotherapy tumor microenvironment. |
HostingRepository | PRIDE |
AnnounceDate | 2022-03-14 |
AnnouncementXML | Submission_2022-03-14_04:59:28.447.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Jackson Fatherree |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-03-02 08:00:00 | ID requested | |
⏵ 1 | 2022-03-14 04:59:28 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: breast cancer, extracellular matrix, chemotherapy |
Contact List
Madeleine J Oudin |
contact affiliation | Department of Biomedical Engineering, Tufts University |
contact email | madeleine.oudin@tufts.edu |
lab head | |
Jackson Fatherree |
contact affiliation | Tufts university |
contact email | jackson.fatherree@tufts.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD032002
- Label: PRIDE project
- Name: Characterization of the Chemotherapy-treated PyMT Matrisome