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PXD032002

PXD032002 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleCharacterization of the Chemotherapy-treated PyMT Matrisome
DescriptionCytotoxic chemotherapy is used to treat many thousands of patients across many cancer types annually. Recent studies have demonstrated that chemotherapy causes systemic response that can be exploited to promote cancer cell survival and dissemination, termed “chemotherapy-induced metastasis. However, there have been no studies investigating how chemotherapy alters the extracellular matrix of breast tumors, or if those changes might help to support metastatic dissemination. Here, we report the first characterization of the chemotherapy-treated breast cancer matrisome using the MMTV-PyMT transgenic mouse model of breast cancer. We identify distinct changes induced by different cytotoxic chemotherapies. In particular, we identify collagen IV as significantly associated with taxane-based chemotherapy treatment. Biological validation confirmed collagen IV as chemotherapy-associated and identified collagen IV-driven Src and FAK signaling as important mediators of invasion in the post-chemotherapy tumor microenvironment.
HostingRepositoryPRIDE
AnnounceDate2022-03-14
AnnouncementXMLSubmission_2022-03-14_04:59:28.447.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJackson Fatherree
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-03-02 08:00:00ID requested
12022-03-14 04:59:28announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: breast cancer, extracellular matrix, chemotherapy
Contact List
Madeleine J Oudin
contact affiliationDepartment of Biomedical Engineering, Tufts University
contact emailmadeleine.oudin@tufts.edu
lab head
Jackson Fatherree
contact affiliationTufts university
contact emailjackson.fatherree@tufts.edu
dataset submitter
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Dataset FTP location
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