PXD032002

PXD032002 is an original dataset announced via ProteomeXchange.

Title	Characterization of the Chemotherapy-treated PyMT Matrisome
Description	Cytotoxic chemotherapy is used to treat many thousands of patients across many cancer types annually. Recent studies have demonstrated that chemotherapy causes systemic response that can be exploited to promote cancer cell survival and dissemination, termed “chemotherapy-induced metastasis. However, there have been no studies investigating how chemotherapy alters the extracellular matrix of breast tumors, or if those changes might help to support metastatic dissemination. Here, we report the first characterization of the chemotherapy-treated breast cancer matrisome using the MMTV-PyMT transgenic mouse model of breast cancer. We identify distinct changes induced by different cytotoxic chemotherapies. In particular, we identify collagen IV as significantly associated with taxane-based chemotherapy treatment. Biological validation confirmed collagen IV as chemotherapy-associated and identified collagen IV-driven Src and FAK signaling as important mediators of invasion in the post-chemotherapy tumor microenvironment.
HostingRepository	PRIDE
AnnounceDate	2022-03-14
AnnouncementXML	Submission_2022-03-14_04:59:28.447.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jackson Fatherree
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2022-03-02 08:00:00	ID requested
⏵ 1	2022-03-14 04:59:28	announced

Dataset with its publication pending

submitter keyword: breast cancer, extracellular matrix, chemotherapy

Madeleine J Oudin
contact affiliation	Department of Biomedical Engineering, Tufts University
contact email	madeleine.oudin@tufts.edu
lab head
Jackson Fatherree
contact affiliation	Tufts university
contact email	jackson.fatherree@tufts.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/03/PXD032002

PRIDE project URI

• PRIDE
  1. PXD032002
     1. Label: PRIDE project
     2. Name: Characterization of the Chemotherapy-treated PyMT Matrisome