PXD032001

PXD032001 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Mining gastric cancer cellular quantitative phosphotyrosine proteomics data to analyse the signiling cascade regulated my CAMKK2 in gastric cancer
Description	Gastric cancer is a global health concern. Tyrosine kinases (TKs) are important mediators of signaling cascades, which regulate diverse biological processes like growth, differentiation, metabolism, and apoptosis in response to external and internal stimuli. Molecular alterations in various signaling pathways have been implicated in the development and late-stage progression/metastasis of gastric cancer. Dysregulation of TK’s are reported to be involved in different malignancies.1 Tyrosine kinases represent a major portion of all oncoproteins that play a transforming role in a plethora of cancers.. This study aimed at analysing the phosphotyrosine proteome change upon inhibition of CAMKK2 in gastric cancer cells using LC-MS/MS based quantitative inhibition proteomic approach. A label free based quantitative approach was used to identify the significantly altered phosphorylations upon inhibition of CAMKK2. Gene Ontology (GO) analysis and pathway analysis was done for the significantly altered proteins and was later validated by immunoblotting.
HostingRepository	PRIDE
AnnounceDate	2022-06-09
AnnouncementXML	Submission_2022-06-09_09:13:00.365.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Aditi Chatterjee
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue
Instrument	Orbitrap Fusion

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2022-03-02 07:28:46	ID requested
⏵ 1	2022-06-09 09:13:01	announced

Publication List

Najar MA, Arefian M, Sidransky D, Gowda H, Prasad TSK, Modi PK, Chatterjee A, Tyrosine Phosphorylation Profiling Revealed the Signaling Network Characteristics of CAMKK2 in Gastric Adenocarcinoma. Front Genet, 13():854764(2022) [pubmed]

Najar MA, Arefian M, Sidransky D, Gowda H, Prasad TSK, Modi PK, Chatterjee A, Tyrosine Phosphorylation Profiling Revealed the Signaling Network Characteristics of CAMKK2 in Gastric Adenocarcinoma. Front Genet, 13():854764(2022) [pubmed]

Keyword List

submitter keyword: Gastric cancer, Proteomics, Data Mining, CAMKK2, STO-609, Mass spectrometry, STAT3

submitter keyword: Gastric cancer, Proteomics, Data Mining, CAMKK2, STO-609, Mass spectrometry, STAT3

Contact List

Aditi chatterjee
contact affiliation	Center for Systems Biology and Molecular Medicine, Yenepoya (Deemed to be University), Mangalore 575018, India
contact email	aditixchatterjee@gmail.com
lab head
Aditi Chatterjee
contact affiliation	Institute of Bioinformatics, Bangalore, Karnataka, India
contact email	aditixchatterjee@gmail.com
dataset submitter

Full Dataset Link List

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PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/06/PXD032001

PRIDE project URI

Repository Record List

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