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PXD031996

PXD031996 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteomic analysis of follicular fluid of Patients with Polycystic Ovary Syndrome
DescriptionPolycystic ovary syndrome (PCOS) is a common disorder encompassing reproductive, metabolic, and endocrine abnormalities, affecting 5 to 10% of women of reproductive age.To reveal the differences in proteomic profiles of follicular fluid between patients with and without PCOS and explore possible mechanisms underlying PCOS.Follicular fluid samples were collected from 9 infertile patients with PCOS and 9 infertile patients without PCOS. Quantitative proteomics analysis based on mass spectrometry was used to measure the protein levels and understand the protein networks. The tandem mass tag (TMT) based proteomics technology and bioinformatics analysis were used to determine the differentially expressed proteins(DEPs). : In this study, we have identified a total of 1216 proteins,these included 70 DEPs, in which 32 proteins were upregulated, and 38 proteins were downregulated. The bioinformatics analyses revealed multiple biological functions associated with these DEPs, some DEPs were enriched in the immune and metabolic-related biological processes in PCOS patients.
HostingRepositoryPRIDE
AnnounceDate2023-11-14
AnnouncementXMLSubmission_2023-11-14_07:45:41.341.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterwenqi wang
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-03-02 02:57:56ID requested
12022-10-14 14:16:46announced
22023-11-14 07:45:43announced2023-11-14: Updated project metadata.
Publication List
Wang W, Jiang Q, Niu Y, Ding Q, Yang X, Zheng Y, Hao J, Wei D, Proteomics and bioinformatics analysis of follicular fluid from patients with polycystic ovary syndrome. Front Mol Biosci, 9():956406(2022) [pubmed]
Keyword List
submitter keyword: proteomics, follicular fluid, tandem mass tag,polycystic ovary syndrome
Contact List
Daimin Wei
contact affiliationCenter for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, China
contact emailsdweidaimin@163.com
lab head
wenqi wang
contact affiliationshandong university
contact email646788656@qq.com
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
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