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PXD031952

PXD031952 is an original dataset announced via ProteomeXchange.

Dataset Summary
Titlethe role of neutrophil-produced collagen in skin injury
Descriptionto assess the role of neutrophil-produced collagen in skin injury. 3 mouse groups (WT, Mrp8-Cre;TGFbR2-floxed and Mrp8-Cre;iDTR) were subjected to an ear injury by piercing. A limited area around the wound was dissected (6-10 mg tissue) and subjected to ECM extraction and TMT proteomics analysis. From each animal, an equivalent amount of skin from the other (healthy) ear was also excised and used as an internal control. 4 biological replicates per condition (WT, A and B) with 2 samples per animal (injured and healthy control) were distributed in three independent TMT 10-plex experiments. Samples from the same animal were kept together in the same TMT experiment. In each TMT experiment one of the channels was reserved for a common internal standard (I.S.) made by pooling the 24 peptide samples.
HostingRepositoryPRIDE
AnnounceDate2025-02-28
AnnouncementXMLSubmission_2025-02-28_02:04:37.295.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterElena Bonzon-Kulichenko
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListTMT6plex-126 reporter+balance reagent acylated residue; monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue
InstrumentOrbitrap Fusion
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-02-28 12:25:09ID requested
12025-02-28 02:04:37announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: neutrophil collagen hydroxilation inflammation
Contact List
Jesús Vázquez Cobos
contact affiliationCardiovascular Proteomics Laboratory & Proteomics Unit Vascular Pathophysiology Area Centro Nacional de Investigaciones Cardiovasculares Melchor Fernández Almagro núm. 3 28029 Madrid
contact emailjvazquez@cnic.es
lab head
Elena Bonzon-Kulichenko
contact affiliationUniversity of Castilla-La Mancha
contact emailelena.bonzon@uclm.es
dataset submitter
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Dataset FTP location
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