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PXD031929

PXD031929 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteomic Alterations Associated with Residual Disease in Neoadjuvant Chemotherapy Treated Ovarian Cancer Tissues
DescriptionOptimal cytoreduction to no residual disease (R0) correlates with improved disease outcome in the management of high-grade serous ovarian cancer (HGSOC) patients. Neoadjuvant chemotherapy (NACT) followed by interval debulking surgery (IDS) offers an alternate approach to management of HGSOC patients to achieve complete resection. This study assessed proteomic alterations in matched, chemotherapy naïve and NACT-treated patients tumors obtained from HGSOC patients with suboptimal (R1) versus optimal (R0) debulking at IDS. We describe distinct proteome profiles in pre- and post-NACT HGSOC tumors correlating with residual disease status providing prognostic biomarkers for residual disease at IDS as well as candidate proteins associated with NACT resistance warranting further pre-clinical investigation.
HostingRepositoryPRIDE
AnnounceDate2022-10-05
AnnouncementXMLSubmission_2022-10-05_09:45:49.774.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterThomas Conrads
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListTMT6plex-126 reporter+balance reagent acylated residue; monohydroxylated residue
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-02-28 03:14:59ID requested
12022-10-05 09:45:50announced
Publication List
10.1186/S12014-022-09372-Y;
Keyword List
submitter keyword: High-Grade Serous Ovarian Cancer, Neoadjuvant Chemotherapy, Residual Disease, Precision Medicine, Proteomics, Mass Spectrometry
Contact List
Thomas P. Conrads
contact affiliationInova Health System
contact emailconrads@whirc.org
lab head
Thomas Conrads
contact affiliationInova Health System
contact emailconrads@whirc.org
dataset submitter
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Dataset FTP location
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