PXD031908

PXD031908 is an original dataset announced via ProteomeXchange.

Title	B-cell compartment hyperactivation in PHIV
Description	Despite a successful antiretroviral therapy (ART), adolescents living with perinatally acquired HIV (PHIV) experience signs of B-cell hyperactivation with expansion of 'namely' atypical B-cell phenotypes, including double negative (CD27-IgD-) and termed age associated (ABCs) B-cells(T-bet+CD11c+), which may result in reduced cell functionality, including loss of vaccine-induced immunological memory and higher risk of developing B-cells associated tumors. In this context,perinatally HIV infected children (PHIV) deserve particular attention, given their life-long exposure to chronic immune activation.
HostingRepository	PRIDE
AnnounceDate	2022-03-03
AnnouncementXML	Submission_2022-03-03_11:14:53.482.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Benoit Fatou
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	amidated residue; monohydroxylated residue; iodoacetamide derivatized residue; deamidated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2022-02-28 01:05:23	ID requested
⏵ 1	2022-03-03 11:14:53	announced

Dataset with its publication pending

submitter keyword: perinatal HIV/AIDS, immune activation, late ART, proteomic profiling, B-cell hyperactivation, exhausted T-cells, T-bet, CD11c, caHIV-1 RNA

Hanno Steen
contact affiliation	Department of Pathology, Boston Children's Hospital / Harvard Medical School
contact email	hanno.steen@childrens.harvard.edu
lab head
Benoit Fatou
contact affiliation	Boston Children's Hospital, Boston, MA
contact email	benoit.fatou@childrens.harvard.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/03/PXD031908

PRIDE project URI

• PRIDE
  1. PXD031908
     1. Label: PRIDE project
     2. Name: B-cell compartment hyperactivation in PHIV