PXD031905
PXD031905 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomic and Phosphoproteomic Analyses of the Molecular Mechanisms of Periodontal Ligament Stem Cell Osteogenic Differentiation |
| Description | Periodontal ligament stem cells (PDLSCs) are optimal seed cells for periodontal regeneration; thus, exploration of the mechanisms regulating PDLSCs osteogenic differentiation is critical. Here, tandem mass tag quantitative proteomics and phosphoproteomic analyses of human PDLSCs were carried out after osteogenic differentiation for 14 days. Proteomic analyses identified 314 differentially expressed proteins (DEPs) that were predicted to be mostly extracellular. Gene ontology and pathway enrichment analyses revealed that the mineral absorption signaling pathway was significantly involved. For phosphoproteomics, un-normalized data identified 1016 differentially expressed phosphorylation sites (DEPSs) corresponded to 380 DEPs, whereas in normalized data, 3030 DEPSs were identified, corresponding to 358 DEPs. Overlapping of these data identified 16 phosphorylated DEPs, among which tetratricopeptide repeat protein 17, stanniocalcin-1, and extracellular superoxide dismutase [Cu-Zn] were significantly related. Kyoto |
| HostingRepository | iProX |
| AnnounceDate | 2022-02-25 |
| AnnouncementXML | Submission_2024-02-27_18:09:26.933.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Tingting Ning |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | phosphorylated residue |
| Instrument | Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2022-02-27 21:44:45 | ID requested | |
| ⏵ 1 | 2024-02-27 18:09:27 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Periodontal ligament stem cells, osteogenic differentiation, phosphoproteomics, proteomic |
Contact List
| He Wang | |
|---|---|
| contact affiliation | Stomatological Hospital, Southern Medical University |
| contact email | wongherb@126.com |
| lab head | |
| Tingting Ning | |
| contact affiliation | Department of Endodontics, Stomatological Hospital, Southern Medical University |
| contact email | 754326360@qq.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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