PXD031885

PXD031885 is an original dataset announced via ProteomeXchange.

Title	DEK/NUP214 SILAC interactormics analysis
Description	Among most of leukemogenic fusion proteins the aberrant localization that the translocation partners are forced in when compared to their wt counterparts contributes to leukemogenesis most likely by a sequester of interaction partners. The aim was to disclose the role of localization of DEK/NUP214 and the related sequester of proteins interacting with DEK/NUP214 for the induction t(6;9)- AML. The pathways indispensable for the induction of the leukemogenic phenotype were worked out by comparing the interactome of the full-length fusion protein to that of biologiaclly-dead mutants.
HostingRepository	PRIDE
AnnounceDate	2022-10-14
AnnouncementXML	Submission_2022-10-14_07:10:30.598.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	MartinRuthardt
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	isotope labeled residue
Instrument	LTQ Orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2022-02-24 10:27:48	ID requested
⏵ 1	2022-10-14 07:10:30	announced

Dataset with its publication pending

submitter keyword: SILAC,DEK/NUP214, interactome

MartinRuthardt
contact affiliation	DCG, Hematology, Cardiff University, UK
contact email	ruthardtm@cardiff.ac.uk
lab head
MartinRuthardt
contact affiliation	Division of Cancer and Genetics, Medical School, Cardiff University, Cardiff, UK
contact email	ruthardtm@cardiff.ac.uk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/10/PXD031885

PRIDE project URI

• PRIDE
  1. PXD031885
     1. Label: PRIDE project
     2. Name: DEK/NUP214 SILAC interactormics analysis