PXD031853

PXD031853 is an original dataset announced via ProteomeXchange.

Title	CTNNBL1 restricts HIV-1 replication
Description	Retroviral integration is mediated by a unique enzymatic process shared by all retroviruses and retrotransposons. During integration, double-stranded linear viral DNA is inserted into the host genome in a process catalyzed by viral-encoded integrase. However, host cell defenses against HIV-1 integration are not clear. This study identifies -catenin-like protein 1 (CTNNBL1) as a potent inhibitor of HIV-1 integration via association with viral IN and its cofactor, lens epithelium-derived growth factor/p75. CTNNBL1 overexpression blocks HIV-1 integration and inhibits viral replication, whereas CTNNBL1 depletion significantly upregulates HIV-1 integration into the genome of various target cells. Further, CTNNBL1 expression is downregulated in CD4+ T cells by activation, and CTNNBL1 depletion also facilitates HIV-1 integration in resting CD4+ T cells. Thus, host cells may employ CTNNBL1 to inhibit HIV-1 integration into the genome. This finding suggests a strategy for the treatment of HIV infections.
HostingRepository	iProX
AnnounceDate	2022-02-24
AnnouncementXML	Submission_2022-02-23_17:55:46.088.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Guoxin Liang
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	phosphorylated residue; ubiquitination signature dipeptidyl lysine
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2022-02-23 17:55:33	ID requested
⏵ 1	2022-02-23 17:55:46	announced

Dataset with its publication pending

submitter keyword: CTNNBL1, HIV-1, LC-MC, IP, Ubiquitination, Phosphorylation

Guoxin Liang
contact affiliation	China Medical University
contact email	gxliang@cmu.edu.cn
lab head
Guoxin Liang
contact affiliation	China Medical University
contact email	gxliang@cmu.edu.cn
dataset submitter

iProX dataset URI