PXD031794 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | An unconventional integrin b3 and CD103 heterodimer improves the anti-tumor immunity of tissue-resident T cells |
Description | Current cancer immunotherapies promote recovery of CD103+ tissue-resident memory T cells (Trm) population of the tumor-infiltrating T lymphocytes (TILs). However, not all treated patients exhibit improved anti-tumor immunity and survival, likely due to the immunophenotypical diversity among the CD103+ Trm TILs. Utilising multifaceted proteomics approaches and patients’ clinical analyses, we discovered an unusual subset of CD8+ Trm TILs expressing non-canonical integrin β3 early during T cells activation. The integrin β3 surprisingly heterodimerises with CD103 on T cells, leading to unconventional granulysin-mediated cytotoxicity, elevated alternative bioenergy usage and efficient T cell migration, with minimal overall exhaustion. Importantly, early-stage non-small cell lung carcinoma (NSCLC) patients with enriched presence of integrin β3+CD103+ Trm TILs exhibited better clinical prognosis, with improved T cell immunophenotype, hence confirming the beneficial role of this unusual subset of Trm TILs. These unconventional anti-tumor T cell features provide new avenues and future opportunities for designing better translational immunotherapy strategies. |
HostingRepository | PRIDE |
AnnounceDate | 2024-02-14 |
AnnouncementXML | Submission_2024-02-14_03:29:24.257.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Svenja Hester |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-02-21 05:30:05 | ID requested | |
⏵ 1 | 2024-02-14 03:29:24 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: XCR1, granulysin,ITGB3, tissue-resident, cancer immunotherapy, amino acids, cancer-specific T cells |
Contact List
Professor Tao Dong |
contact affiliation | Nuffield Department of Medicine, University of Oxford, OX3 7FZ, U.K. |
contact email | tao.dong@ndm.ox.ac.uk |
lab head | |
Svenja Hester |
contact affiliation | Nuffield Department of Medicine |
contact email | svenja.hester@ndm.ox.ac.uk |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD031794
- Label: PRIDE project
- Name: An unconventional integrin b3 and CD103 heterodimer improves the anti-tumor immunity of tissue-resident T cells