PXD031789

PXD031789 is an original dataset announced via ProteomeXchange.

Title	HISTOLOGICAL AND PROTEOMIC CHARACTERIZATION OF MUSCULOSKELETAL AMYLOIDOMAS
Description	We report the histological and immunohistochemical features of four cases of musculoskeletal amyloidoma in association with combined laser capture microdissection (LCM) of Congo Red (CR)-positive regions with a recent microproteomics workflow that improves the sensitivity of the analysis in order to confirm the nature of the protein deposit. Proteomics techniques allowed to elucidate the nature of the amyloid protein deposit, improving the results obtained by immunohistochemistry (IHC). IHC results were confirmed in two cases while laser-capture microdissection coupled with bottom-up microproteomics was necessary to type the other two cases, for which IHC was inconclusive.
HostingRepository	PRIDE
AnnounceDate	2025-07-14
AnnouncementXML	Submission_2025-07-13_16:05:04.468.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Francesco Greco
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2022-02-21 03:32:47	ID requested
⏵ 1	2025-07-13 16:05:05	announced

10.32074/1591-951x-939;

Gaeta R, Greco F, Anastasi F, Andreani L, Capanna R, McDonnell LA, Franchi A, Histological and proteomic characterization of musculoskeletal amyloidomas. Pathologica, 117(3):278-287(2025) [pubmed]

submitter keyword: proteomics,amyloidoma, LC-MS/MS

Liam A. McDonnell
contact affiliation	Fondazione Pisana per la Scienza ONLUS, 56017 San Giuliano Terme (PI), Italy
contact email	l.a.mcdonnell@outlook.com
lab head
Francesco Greco
contact affiliation	Scuola Superiore Sant'Anna, Pisa
contact email	fr.greco@santannapisa.it
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/07/PXD031789

PRIDE project URI

• PRIDE
  1. PXD031789
     1. Label: PRIDE project
     2. Name: HISTOLOGICAL AND PROTEOMIC CHARACTERIZATION OF MUSCULOSKELETAL AMYLOIDOMAS