PXD031640

PXD031640 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Proteomic signatures of schizophrenia-sourced iPSC-derived astrocytes
Description	Schizophrenia is a complex and severe neuropsychiatric disorder, with a wide range of debilitating symptoms. Several aspects of its multifactorial complexity are still unknown, and some are accepted to be an early developmental deficiency with a more specifically neurodevelopmental origin. ??Molecular and functional abnormalities in astrocytes play a role in the etiology and pathogenesis of schizophrenia. In this study, human induced pluripotent stem cells (hiPSC)-derived astrocytes from schizophrenia patients were investigated regarding their proteome, inflammatory responses, and their secretome effect on vascularization. Proteomic analysis revealed alterations in proteins related to immune function and vascularization. Taken together, our results suggest that schizophrenia astrocytes are immunologically dysfunctional which might affect vascularization through secreted factors.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:45:11.323.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Juliana Minardi Nascimento
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Synapt MS

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2022-02-13 13:15:36	ID requested
1	2023-04-27 09:34:01	announced
2	2023-11-14 08:54:52	announced	2023-11-14: Updated project metadata.
⏵ 3	2024-10-22 05:45:11	announced	2024-10-22: Updated project metadata.

Publication List

10.1038/S41380-022-01830-1;

10.1038/S41380-022-01830-1;

Keyword List

submitter keyword: SCZ, glial cells,strocyte, disease, hiPSC, proteome

submitter keyword: SCZ, glial cells,strocyte, disease, hiPSC, proteome

Contact List

Daniel Martins-de-Souza
contact affiliation	Lab of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, SP, Brazil
contact email	dmsouza@unicamp.br
lab head
Juliana Minardi Nascimento
contact affiliation	University of Campinas
contact email	juminardi@gmail.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/04/PXD031640
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/04/PXD031640

PRIDE project URI

Repository Record List

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