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PXD031637

PXD031637 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteomic profiling identifies co-regulated expression of splicing factors as a characteristic feature of intravenous leiomyomatosis
DescriptionIn this work, we undertake a comparative mass spectrometry-based proteomic analysis of intravenous leiomyoma (IVLM) and other smooth muscle tumours (uterine leiomyoma (uLM), soft tissue leiomyoma (stLM) and benign metastatic keiomyoma (BML). By utilising sequential window acquisition of all theoretical fragment ion spectra mass spectrometry (SWATH-MS), we quantified >2,400 proteins from FFPE samples and demonstrate that at the protein level, IVLM is characterised by the unique co-regulated expression of splicing factors that comprise the spliceosome.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_05:39:00.969.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterLukas Krasny
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListmonohydroxylated residue; deamidated residue; iodoacetamide derivatized residue
InstrumentTripleTOF 5600
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-02-13 12:58:02ID requested
12022-08-12 01:40:14announced
22024-10-22 05:39:03announced2024-10-22: Updated project metadata.
Publication List
10.3390/cancers14122907;
Krasny L, Wilding CP, Perkins E, Arthur A, Guljar N, Jenks AD, Fisher C, Judson I, Thway K, Jones RL, Huang PH, Proteomic Profiling Identifies Co-Regulated Expression of Splicing Factors as a Characteristic Feature of Intravenous Leiomyomatosis. Cancers (Basel), 14(12):(2022) [pubmed]
Keyword List
submitter keyword: Human, TripleTOF 5600+, SWATH-MS, FFPE tissue, LC-MS/MS
Contact List
Paul Huang
contact affiliationMolecular and Systems Oncology Team Institute of Cancer Research London, UK
contact emailPaul.Huang@icr.ac.uk
lab head
Lukas Krasny
contact affiliationThe Institute of Cancer Research
contact emailLukas.Krasny@icr.ac.uk
dataset submitter
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Dataset FTP location
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PRIDE project URI
Repository Record List
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