PXD031637 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteomic profiling identifies co-regulated expression of splicing factors as a characteristic feature of intravenous leiomyomatosis |
Description | In this work, we undertake a comparative mass spectrometry-based proteomic analysis of intravenous leiomyoma (IVLM) and other smooth muscle tumours (uterine leiomyoma (uLM), soft tissue leiomyoma (stLM) and benign metastatic keiomyoma (BML). By utilising sequential window acquisition of all theoretical fragment ion spectra mass spectrometry (SWATH-MS), we quantified >2,400 proteins from FFPE samples and demonstrate that at the protein level, IVLM is characterised by the unique co-regulated expression of splicing factors that comprise the spliceosome. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_05:39:00.969.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Lukas Krasny |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue |
Instrument | TripleTOF 5600 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-02-13 12:58:02 | ID requested | |
1 | 2022-08-12 01:40:14 | announced | |
⏵ 2 | 2024-10-22 05:39:03 | announced | 2024-10-22: Updated project metadata. |
Publication List
10.3390/cancers14122907; |
Krasny L, Wilding CP, Perkins E, Arthur A, Guljar N, Jenks AD, Fisher C, Judson I, Thway K, Jones RL, Huang PH, Proteomic Profiling Identifies Co-Regulated Expression of Splicing Factors as a Characteristic Feature of Intravenous Leiomyomatosis. Cancers (Basel), 14(12):(2022) [pubmed] |
Keyword List
submitter keyword: Human, TripleTOF 5600+, SWATH-MS, FFPE tissue, LC-MS/MS |
Contact List
Paul Huang |
contact affiliation | Molecular and Systems Oncology Team Institute of Cancer Research London, UK |
contact email | Paul.Huang@icr.ac.uk |
lab head | |
Lukas Krasny |
contact affiliation | The Institute of Cancer Research |
contact email | Lukas.Krasny@icr.ac.uk |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD031637
- Label: PRIDE project
- Name: Proteomic profiling identifies co-regulated expression of splicing factors as a characteristic feature of intravenous leiomyomatosis