PXD031632

PXD031632 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Crosslinking/mass spectrometry analysis of Fanconi anemia (FA) pathway FANCD2-FANCI complexes
Description	DNA interstrand crosslinks (ICLs) are repaired by the Fanconi anemia (FA) pathway. The FA pathway is activated by phosphorylation of FANCI in FANCD2-FANCI complex. To investigate how phosphorylation regulates FA pathway activation and function, recombinant FANCD2-FANCI complexes prepared using either the wild-type FANCI or the phosphomimetic FANCI, were comparied using crosslinking/mass spectrometry.
HostingRepository	jPOST
AnnounceDate	2022-11-18
AnnouncementXML	Submission_2022-11-18_04:24:59.827.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD031632
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Zhuo Chen
SpeciesList	scientific name: cellular organisms; NCBI TaxID: 131567;
ModificationList	S-carboxamidomethyl-L-cysteine; L-methionine sulfoxide; unknown modification; unknown modification; unknown modification
Instrument	Orbitrap Fusion Lumos

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2022-02-12 18:49:54	ID requested
⏵ 1	2022-11-18 04:25:00	announced

Publication List

Sijacki T, Alc, ó, n P, Chen ZA, McLaughlin SH, Shakeel S, Rappsilber J, Passmore LA, The DNA-damage kinase ATR activates the FANCD2-FANCI clamp by priming it for ubiquitination. Nat Struct Mol Biol, 29(9):881-890(2022) [pubmed]

Sijacki T, Alc, ó, n P, Chen ZA, McLaughlin SH, Shakeel S, Rappsilber J, Passmore LA, The DNA-damage kinase ATR activates the FANCD2-FANCI clamp by priming it for ubiquitination. Nat Struct Mol Biol, 29(9):881-890(2022) [pubmed]

Keyword List

submitter keyword: Fanconi anemia (FA) pathway, FANCI phosphorylation, crosslinking/mass spectrometry

submitter keyword: Fanconi anemia (FA) pathway, FANCI phosphorylation, crosslinking/mass spectrometry

Contact List

Juri Rappsilber
lab head
Zhuo Chen
contact affiliation	Technische Universität Berlin
dataset submitter

Full Dataset Link List

jPOST dataset URI
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jPOST dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST001474/