PXD031574

PXD031574 is an original dataset announced via ProteomeXchange.

Title	Multi-omics evaluation of SARS-CoV-2 infected mouse lungs reveals dynamics of host responses
Description	The outbreak of Coronavirus disease 2019 (COVID-19) throughout the world has caused millions of death, while the dynamics of host responses and the underlying regulation mechanisms during SARS-CoV-2 infection are not well depicted. Lung tissues from a mouse model sensitized to SARS-CoV-2 infection were serially collected at different time points for evaluation of transcriptome, proteome and phosphoproteome. We showed the ebb and flow of several host responses in the lung across viral infection. The signaling pathways and kinases regulating networks were alternated at different phases of infection. Our study not only revealed the dynamics of lung pathophysiology and their underlying molecular mechanisms during SARS-CoV-2 infection, but also highlighted some molecules and signaling pathways that might guide future investigations on COVID-19 therapies.
HostingRepository	PRIDE
AnnounceDate	2022-05-25
AnnouncementXML	Submission_2022-05-25_03:46:04.742.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xiao Xiao Tang
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	O-phosphopantetheine-L-serine
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2022-02-10 13:30:08	ID requested
⏵ 1	2022-05-25 03:46:05	announced

Wang ZN, Yang XS, Sun J, Zhao JC, Zhong NS, Tang XX, Multi-omics evaluation of SARS-CoV-2 infected mouse lungs reveals dynamics of host responses. iScience, 25(3):103967(2022) [pubmed]

submitter keyword: SARS-CoV-2

Lung host response

Dynamics

Mouse model, Multi-omics analysis

Xiao Xiao Tang
contact affiliation	Guangzhou Medical University
contact email	tangxiaoxiao@gird.cn
lab head
Xiao Xiao Tang
contact affiliation	Guangzhou Medical University
contact email	tangxiaoxiao@gird.cn
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/04/PXD031574

PRIDE project URI

• PRIDE
  1. PXD031574
     1. Label: PRIDE project
     2. Name: Multi-omics evaluation of SARS-CoV-2 infected mouse lungs reveals dynamics of host responses