PXD031556

PXD031556 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Molecular composition of serum exosomes could discriminate rectal cancer patients with different responses to neoadjuvant radiotherapy
Description	Exosomes may be used as biomarkers for the prediction and monitoring of response to anti-cancer treatment, yet relevant knowledge is very limited in the case of rectal cancer. Here we applied a combined proteomic and metabolomic approach to reveal exosome components connected with different responses to neoadjuvant radiotherapy in this group of patients and processes associated with identified discriminatory molecules. Moreover, the composition of serum-derived exosomes and a whole plasma was analyzed in parallel to compare the biomarker potential of both specimens, which revealed the highest capacity of exosome proteome to discriminate samples of patients with different responses to radiotherapy.
HostingRepository	PRIDE
AnnounceDate	2022-04-04
AnnouncementXML	Submission_2022-04-03_20:21:54.916.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Lukasz Marczak
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2022-02-09 12:13:19	ID requested
⏵ 1	2022-04-03 20:21:55	announced

Publication List

Strybel U, Marczak L, Zeman M, Polanski K, Miela, ń, czyk Ł, Klymenko O, Samelak-Czajka A, Jackowiak P, Smolarz M, Chekan M, Zembala-No, ż, y, ń, ska E, Widlak P, Pietrowska M, Wojakowska A, Molecular Composition of Serum Exosomes Could Discriminate Rectal Cancer Patients with Different Responses to Neoadjuvant Radiotherapy. Cancers (Basel), 14(4):(2022) [pubmed]

Strybel U, Marczak L, Zeman M, Polanski K, Miela, ń, czyk Ł, Klymenko O, Samelak-Czajka A, Jackowiak P, Smolarz M, Chekan M, Zembala-No, ż, y, ń, ska E, Widlak P, Pietrowska M, Wojakowska A, Molecular Composition of Serum Exosomes Could Discriminate Rectal Cancer Patients with Different Responses to Neoadjuvant Radiotherapy. Cancers (Basel), 14(4):(2022) [pubmed]

Keyword List

submitter keyword: rectal cancer
small extracellular vesicles
exosomes
radiotherapy
plasma
proteomics

submitter keyword: rectal cancer

small extracellular vesicles

exosomes

radiotherapy

plasma

proteomics

Contact List

Lukasz Marczak
contact affiliation	Institute of Bioorganic Chemistry Polish Academy of Sciences
contact email	lukasmar@ibch.poznan.pl
lab head
Lukasz Marczak
contact affiliation	Institute of Bioorganic Chemistry Polish Academy of Sciences
contact email	lukasmar@ibch.poznan.pl
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/04/PXD031556
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/04/PXD031556

PRIDE project URI

Repository Record List

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