PXD031523

PXD031523 is an original dataset announced via ProteomeXchange.

Title	ATAD3A heterzygous AD mouse brain, LC-MS
Description	Predisposition to Alzheimer's disease (AD) may arise from lipid metabolism perturbation, however, the underlying mechanism remains elusive. Here, we identify ATAD3A, a mitochondrial AAA-ATPase, as a molecular switch that links cholesterol metabolism impairment to AD phenotypes. In neuronal models of AD, the 5XFAD mouse model and post-mortem AD brains, ATAD3A is oligomerized and accumulated at the mitochondria-associated ER membranes (MAMs), where it induces cholesterol accumulation. Suppressing ATAD3A oligomerization by heterozygous ATAD3A knockout normalizes brain cholesterol turnover and MAM integrity, suppresses APP processing and synaptic loss, and consequently reduces AD neuropathology and cognitive deficits in AD transgenic mice. These findings reveal a role for ATAD3A oligomerization in AD pathogenesis and suggest ATAD3A as a potential therapeutic target for AD.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:31:12.791.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xin Qi
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ; LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2022-02-09 05:02:45	ID requested
1	2022-02-11 06:48:26	announced
⏵ 2	2024-10-22 05:31:13	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

submitter keyword: LC-MS,ATAD3A heterzygous, mouse brain

Xin Qi
contact affiliation	Case Western Reserve University School of Medicine
contact email	xxq38@case.edu
lab head
Xin Qi
contact affiliation	Case Western Reserve University
contact email	xxq38@case.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/02/PXD031523

PRIDE project URI

• PRIDE
  1. PXD031523
     1. Label: PRIDE project
     2. Name: ATAD3A heterzygous AD mouse brain, LC-MS