PXD031491

PXD031491 is an original dataset announced via ProteomeXchange.

Title	Murine islets identified by TMT-labeled phosphoproteome after short time stimulation with neurotransmitters ACh and NE
Description	Norepinephrine (NE) and acetylcholine (ACh) are important neurotransmitters of sympathetic and parasympathetic nerves, which play antagonistic roles in regulating different islet hormones secretion. Phosphorylation is reported as a critical post-translational modification participates in neural regulation on various physiological activities in islet. However, the molecular mechanisms of these two transmitters in islet are unknown and whether the neuronal regulation is abnormal in diabetes mellitus also unclear. Quantitative phosphoproteome analysis were performed on murine islet after short time stimulation with neurotransmitters NE and ACh to reveal the key moleculars and phosphorylated proteins in islet which participate in the innervation of nerve signaling.
HostingRepository	PRIDE
AnnounceDate	2022-08-12
AnnouncementXML	Submission_2022-08-11_23:56:12.946.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yunqiang He
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	phosphorylated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2022-02-07 08:29:29	ID requested
⏵ 1	2022-08-11 23:56:13	announced

He Y, Fu Q, Sun M, Qian Y, Liang Y, Zhang J, Gao R, Jiang H, Dai H, Liu Y, Xu X, Chen H, Xu K, Yang T, Phosphoproteome reveals molecular mechanisms of aberrant rhythm in neurotransmitter-mediated islet hormone secretion in diabetic mice. Clin Transl Med, 12(6):e890(2022) [pubmed]

submitter keyword: Murine, islet, phosphoproteome, neurotransmitters, TMT-labeled

Tao Yang
contact affiliation	Department of Endocrinology and Metabolism, The First Affiliated Hospital of Nanjing Medical University.
contact email	yangt@njmu.edu.cn
lab head
Yunqiang He
contact affiliation	The First Affiliated Hospital of Nanjing Medical University
contact email	hyq01230929@163.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/08/PXD031491

PRIDE project URI

• PRIDE
  1. PXD031491
     1. Label: PRIDE project
     2. Name: Murine islets identified by TMT-labeled phosphoproteome after short time stimulation with neurotransmitters ACh and NE