PXD031485

PXD031485 is an original dataset announced via ProteomeXchange.

Title	Proteome of fluid from human ovarian small antral follicles reveals insights in folliculogenesis and oocyte maturation.
Description	Follicles of polycystic ovaries (PCO) often become arrested in early antral stages at around 3 to 11 mm in diameter. The condition disturbs dominant follicle selection and may result in altered ovulation and anovulation. During the growth and development of human follicles, the follicular fluid (FF) constitutes the avascular microenvironment in which the oocyte develops and acts as a vehicle for hormone signaling between cues from circulation and follicular cells. Previous proteomics studies performed on FF from women with polycystic ovarian syndrome (PCOS) have revealed information on the protein changes associated with the pathophysiology of this disorder. However, these studies have been conducted on FF samples obtained in connection with oocyte pick-up during ovarian stimulation right at the time of ovulation and are limited to follicular conditions during the follicular phase of the menstrual cycle. This study aimed to detect proteomic alterations in FF from human small antral follicles (hSAF) obtained from women with PCO as compared to normal women.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:55:07.597.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Indira Pla Parada
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2022-02-07 07:36:22	ID requested
1	2022-04-07 03:34:18	announced
⏵ 2	2023-11-14 08:55:08	announced	2023-11-14: Updated project metadata.

Pla I, Sanchez A, Pors SE, Kristensen SG, Appelqvist R, Sahlin KB, Marko-Varga G, Andersen CY, Malm J, Proteomic Alterations in Follicular Fluid of Human Small Antral Follicles Collected from Polycystic Ovaries-A Pilot Study. Life (Basel), 12(3):(2022) [pubmed]

submitter keyword: proteomics, oocyte maturation., small antral follicles,follicular fluid

Johan Malm
contact affiliation	Clinical Chemistry, Department of Translational Medicine, Lund University, Skane University Hospital Malmö, 205 02 Malmö, Sweden.
contact email	johan.malm@med.lu.se
lab head
Indira Pla Parada
contact affiliation	Lund university
contact email	indira.pla_parada@med.lu.se
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/04/PXD031485

PRIDE project URI

• PRIDE
  1. PXD031485
     1. Label: PRIDE project
     2. Name: Proteome of fluid from human ovarian small antral follicles reveals insights in folliculogenesis and oocyte maturation.