PXD031472

PXD031472 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Comprehensive Analysis of Quantitative Proteomics with DIA Mass Spectrometry and ceRNA Network in Intrahepatic Cholestasis of Pregnancy
Description	In this study, we analyze protein expression in placenta of ICP and normal pregnancies via quantitative proteomics of data-independent acquisition (DIA). Our results showed that compared with normal placenta, the differentially expressed proteins in ICP were involved in autophagosome regulation. Among the top 24 differentially expressed proteins, HBG1, SPI1, HBG2, HBE1, FOXK1, KRT72, SLC13A3, MBD2, SP9, GPLD1, MYH7 and BLOC1S1 were associated with ICP development significantly, furthermore, MBD2, SPI1, FOXK1, SLC13A3 was regulated by multiple miRNAs and lncRNAs. On the whole, our study on ICP might provide potential drug targets to improve adverse pregnancy outcomes of ICP patients.
HostingRepository	iProX
AnnounceDate	2022-02-07
AnnouncementXML	Submission_2022-11-03_19:38:31.404.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yan Fang
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2022-02-06 19:53:46	ID requested
⏵ 1	2022-11-03 19:38:32	announced

Publication List

Fang D, Fang Y, Zhang W, Xiang Y, Cheng X, Liang M, Xia H, Comprehensive Analysis of Quantitative Proteomics With DIA Mass Spectrometry and ceRNA Network in Intrahepatic Cholestasis of Pregnancy. Front Cell Dev Biol, 10():854425(2022) [pubmed]

Fang D, Fang Y, Zhang W, Xiang Y, Cheng X, Liang M, Xia H, Comprehensive Analysis of Quantitative Proteomics With DIA Mass Spectrometry and ceRNA Network in Intrahepatic Cholestasis of Pregnancy. Front Cell Dev Biol, 10():854425(2022) [pubmed]

Keyword List

submitter keyword: Intrahepatic cholestasis of pregnancy, Quantitative proteomics, Competing endogenous RNA (ceRNA) Network, Target therapy

submitter keyword: Intrahepatic cholestasis of pregnancy, Quantitative proteomics, Competing endogenous RNA (ceRNA) Network, Target therapy

Contact List

Huimin Xia
contact affiliation	Guangzhou Women and Children's Medical Center
contact email	xia-huimin@foxmail.com
lab head
Yan Fang
contact affiliation	Guangzhou Women and Children's Medical Center
contact email	18602762832@163.com
dataset submitter

Full Dataset Link List

iProX dataset URI

iProX dataset URI