PXD031465 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Different roles of gamma- and beta-actin in the retina |
Description | Lack of cytoplasmic beta-actin gene (Actb) leads to early embryonic lethality in mice, however targeted editing of Actb coding sequence by introducing five point mutations to encode cytoplasmic gamma-actin protein does not affect mouse viability. These mice with beta to gamma actin replacement (Actbc-g mice) develop normally and show no detectable phenotypes at young age, despite complete lack of beta-actin protein. Here we investigated the effect of the replacement of beta-actin with gamma-actin in the retina. |
HostingRepository | PRIDE |
AnnounceDate | 2023-11-14 |
AnnouncementXML | Submission_2023-11-14_08:40:43.625.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD031465 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Dawei Dong |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-02-05 14:08:07 | ID requested | |
1 | 2023-03-11 02:23:54 | announced | |
⏵ 2 | 2023-11-14 08:40:44 | announced | 2023-11-14: Updated project metadata. |
Publication List
Chen L, Vedula P, Tang HY, Dong DW, Kashina AS, Differential N-terminal processing of beta and gamma actin. iScience, 25(10):105186(2022) [pubmed] |
10.6019/PXD031465; |
Keyword List
submitter keyword: mouse, actin, retina |
Contact List
Dawei W Dong |
contact affiliation | University of Pennsylvania |
contact email | dawei.w.dong@gmail.com |
lab head | |
Dawei Dong |
contact affiliation | University of Pennsylvania |
contact email | dawei.w.dong@gmail.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/03/PXD031465 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD031465
- Label: PRIDE project
- Name: Different roles of gamma- and beta-actin in the retina