PXD031462

PXD031462 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Different roles of gamma- and beta-actin in neuronal functions
Description	Lack of cytoplasmic beta-actin gene (Actb) leads to early embryonic lethality in mice, however targeted editing of Actb coding sequence by introducing five point mutations to encode cytoplasmic gamma-actin protein does not affect mouse viability. These mice with beta to gamma actin replacement (Actbc-g mice) develop normally and show no detectable phenotypes at young age, despite complete lack of beta-actin protein. Here we investigated the effect of the replacement of beta-actin with gamma-actin in the brain and the retina --- the tissue where these two cytoplasmic actin isoforms predominate.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:40:36.309.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD031462
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Dawei Dong
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2022-02-05 13:49:16	ID requested
1	2023-03-11 02:20:26	announced
⏵ 2	2023-11-14 08:40:37	announced	2023-11-14: Updated project metadata.

Publication List

10.6019/PXD031462;
Chen L, Vedula P, Tang HY, Dong DW, Kashina AS, Differential N-terminal processing of beta and gamma actin. iScience, 25(10):105186(2022) [pubmed]

10.6019/PXD031462;

Chen L, Vedula P, Tang HY, Dong DW, Kashina AS, Differential N-terminal processing of beta and gamma actin. iScience, 25(10):105186(2022) [pubmed]

Keyword List

submitter keyword: mouse, brain, actin, retina

submitter keyword: mouse, brain, actin, retina

Contact List

Dawei W Dong
contact affiliation	University of Pennsylvania
contact email	dawei.w.dong@gmail.com
lab head
Dawei Dong
contact affiliation	University of Pennsylvania
contact email	dawei.w.dong@gmail.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/03/PXD031462
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/03/PXD031462

PRIDE project URI

Repository Record List

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