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PXD031456

PXD031456 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleTranslational reprogramming in response to accumulating stressors ensures critical threshold levels of Hsp90 for mammalian life
DescriptionThe cytosolic molecular chaperone Hsp90 is essential for eukaryotic life. It is involved in multiple branches of proteostasis and as a molecular capacitor in morphological evolution. Although reduced Hsp90 levels cause phenotypic variations and correlate with aging, whether eukaryotic cells and organisms can tune Hsp90 levels to alleviate physiologically accumulated stress is unknown. To begin to explore this question, we investigated whether and how mice adapt to the deletion of three out of four alleles encoding cytosolic Hsp90, one Hsp90β allele being the only remaining one. Here we have analysed the proteome of mouse tissues (brain, liver, muscle) corresponding to different Hsp90 genotypes, as well as HEK293 cell clones that were knock-out for Hsp90α/β.
HostingRepositoryPRIDE
AnnounceDate2022-09-20
AnnouncementXMLSubmission_2022-09-20_05:18:33.086.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterManfredo Quadroni
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListacetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
InstrumentOrbitrap Fusion
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-02-05 13:34:49ID requested
12022-09-20 05:18:33announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Hsp90α, Hsp90β, proteostasis, stress response, stress adaptation, senescence, aging, natural selection, development.
Contact List
Didier Picard
contact affiliationDépartement de Biologie Cellulaire, Université de Genève
contact emaildidier.picard@unige.ch
lab head
Manfredo Quadroni
contact affiliationUniversity of Lausanne
contact emailmanfredo.quadroni@unil.ch
dataset submitter
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Dataset FTP location
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