PXD031441

PXD031441 is an original dataset announced via ProteomeXchange.

Title	A conserved module regulates receptor kinase signaling in immunity and development
Description	Ligand recognition by cell-surface receptors underlies development and immunity in both animals and plants. Modulating receptor signaling is critical for appropriate cellular responses but the mechanisms ensuring this are poorly understood. Here, we show that signaling by plant receptors for pathogen-associated molecular patterns (PAMPs) in immunity and CLAVATA3/EMBRYO SURROUNDING REGION-RELATED peptides (CLEp) in development employs a similar regulatory module. In the absence of ligand, signaling is dampened through association with specific type-2C protein phosphatases (PP2Cs). Upon activation, PAMP and CLEp receptors phosphorylate divergent cytosolic kinases, which, in turn, phosphorylate the phosphatases, thereby promoting receptor signaling. Our work reveals a regulatory circuit shared between immune and developmental receptor signaling, which may have broader important implications for plant receptor kinase-mediated signaling in general.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:55:19.873.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD031441
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	FRank Menke
SpeciesList	scientific name: Escherichia coli; NCBI TaxID: 562;
ModificationList	phosphorylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2022-02-04 15:28:10	ID requested
1	2022-05-04 06:52:30	announced
⏵ 2	2023-11-14 08:55:20	announced	2023-11-14: Updated project metadata.

10.6019/PXD031441;

submitter keyword: Arabidopsis, Receptor-like cytoplasmic kinases, Poltergeist-like phosphatase,in vitro kinase assay

Frank L.H. Menke
contact affiliation	The Sainsbury Laboratory
contact email	frank.menke@tsl.ac.uk
lab head
FRank Menke
contact affiliation	the Sainsbury laboratory
contact email	Frank.Menke@tsl.ac.uk
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD031441
     1. Label: PRIDE project
     2. Name: A conserved module regulates receptor kinase signaling in immunity and development