PXD031389

PXD031389 is an original dataset announced via ProteomeXchange.

Title	Proteomic profiling of healthy and SLE isolated B-cells
Description	B cells orchestrate the autoimmune responses in patients with systemic lupus erythematosus (SLE), but broad based B-cell directed therapies only show modest efficacy while attenuating humoral immune responses to vaccines and inducing acquired immunodeficiency. used proteomic and transcriptomic analyses of B cells from patients with SLE and healthy individuals and demonstrated a dominant DDR in SLE B cells.
HostingRepository	PRIDE
AnnounceDate	2022-08-26
AnnouncementXML	Submission_2022-08-26_00:32:26.949.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Martina Samiotaki
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue; deamidated residue
Instrument	Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2022-02-01 04:58:46	ID requested
⏵ 1	2022-08-26 00:32:27	announced

Dataset with its publication pending

submitter keyword: B cells

ATR

IRF1

DNA damage response

Systemic lupus erythematosus

autoimmunity

proteomics

Dimitrios Boumpas
contact affiliation	1. Center for Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, 115 27 Athens, Greece. 2. Joint Rheumatology Program, 4th Department of Internal Medicine, Attikon University Hospital, National and Kapodistrian University of Athens Medical School, 124 62 Athens, Greece.
contact email	boumpasd@uoc.gr
lab head
Martina Samiotaki
contact affiliation	Protein Analysis Laboratory B.S.R.C. "Alexander Fleming", Alexander Fleming Street 34 16672, Vari, Greece
contact email	samiotaki@fleming.gr
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/08/PXD031389

PRIDE project URI

• PRIDE
  1. PXD031389
     1. Label: PRIDE project
     2. Name: Proteomic profiling of healthy and SLE isolated B-cells