Senecavirus A (SVA), which is associated with swine vesicular disease, is an emerging pathogen that caused considerable damages to Chinese pig industrial. As a powerful research method, proteomic provides clues for diseases diagnose, medicine targets selection and pathogenic immunity researches. By using of proteomic to study PK-15 cells infected with SVA SDta/2018 strain, this research aimed to obtain insights and clues for investigating pathogenesis of SVA, viral immune escape mechanism and viruses induced impacts to host immune response.