PXD031257

PXD031257 is an original dataset announced via ProteomeXchange.

Title	Abnormal expression of glucose transporter-1 are a driver of early relapse in follicular lymphoma
Description	FL patients with high GLUT1 levels are at increased risk for early relapse and show only limited responses to PI3K inhibitors. The development of new therapies requires an understanding of the changes in their tumor immune microenvironment (TIME). Using novel IMC and proteomics techniques, we comprehensively identified distinguishing features in the TIME as a function of GLUT1 levels. Bioinformatics analyses identified a crosstalk between GLUT1 and TIME in tumor development and suggest that FL patients expressing high GLUT1 may benefit from metabolic-modulating therapies to prevent early relapse.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:40:40.470.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	qingyuan zhang
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2022-01-26 02:25:00	ID requested
1	2023-03-11 02:24:05	announced
⏵ 2	2023-11-14 08:40:41	announced	2023-11-14: Updated project metadata.

Deng Y, Ma J, Zhao S, Yang M, Sun Y, Zhang Q, Expression of glucose transporter-1 in follicular lymphoma affected tumor-infiltrating immunocytes and was related to progression of disease within 24 months. Transl Oncol, 28():101614(2023) [pubmed]

submitter keyword: IMC,GLUT1, early-relapsed follicular lymphoma, PI3K/Akt /mTOR signaling, tumor immunomicroenvironment, proteomic

qingyuan zhang
contact affiliation	Harbin Medical University Cancer Hospital, Heilongjiang Cancer Institute, Harbin 150081, Heilongjiang Province, People’s Republic of China.
contact email	0566@hrbmu.edu.cn
lab head
qingyuan zhang
contact affiliation	Department of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin 150081, Heilongjiang Province, People’s Republic of China.
contact email	0566@hrbmu.edu.cn
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/03/PXD031257

PRIDE project URI

• PRIDE
  1. PXD031257
     1. Label: PRIDE project
     2. Name: Abnormal expression of glucose transporter-1 are a driver of early relapse in follicular lymphoma