PXD031251

PXD031251 is an original dataset announced via ProteomeXchange.

Title	PLATELET PROTEOME REVEALS FEATURES OF CELL DEATH, ANTIVIRAL RESPONSE AND VIRAL REPLICATION IN COVID-19.
Description	This article provides the first proteomic analysis of platelets from COVID-19 patients. Our dataset shows that platelets are reprogrammed during severe COVID-19 and respond with the activation of type I interferon and cell death pathways, indicating platelet participation in the antiviral response. Additionally, identification of proteins involved in translation, mainly in non-surviving, and complete sequencing of SARS-CoV-2 genome call attention to platelets as viral repositories and markers poor prognosis in COVID-19.
HostingRepository	PRIDE
AnnounceDate	2022-08-12
AnnouncementXML	Submission_2022-08-12_01:46:08.349.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Monique Trugilho
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2022-01-26 02:16:45	ID requested
⏵ 1	2022-08-12 01:46:09	announced

Trugilho MRO, Azevedo-Quintanilha IG, Gesto JSM, Moraes ECS, Mandacaru SC, Campos MM, Oliveira DM, Dias SSG, Bastos VA, Santos MDM, Carvalho PC, Valente RH, Hottz ED, Bozza FA, Souza TML, Perales J, Bozza PT, Platelet proteome reveals features of cell death, antiviral response and viral replication in covid-19. Cell Death Discov, 8(1):324(2022) [pubmed]

submitter keyword: PLATELET, PROTEOME, COVID-19

Monique Ramos Oliveira Trugilho
contact affiliation	Center for Technological Development in Health, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil
contact email	mrotrugilho@hotmail.com
lab head
Monique Trugilho
contact affiliation	Center for Technological Development in Health (CDTS/FIOCRUZ)
contact email	mrotrugilho@hotmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/08/PXD031251

PRIDE project URI

• PRIDE
  1. PXD031251
     1. Label: PRIDE project
     2. Name: PLATELET PROTEOME REVEALS FEATURES OF CELL DEATH, ANTIVIRAL RESPONSE AND VIRAL REPLICATION IN COVID-19.