PXD031244

PXD031244 is an original dataset announced via ProteomeXchange.

Title	CROP: A Retromer- PROPPIN complex mediating membrane fission in the endo-lysosomal system
Description	Endo-lysosomal compartments exchange proteins by fusing, fissioning, and through endosomal transport carriers. Thereby, they sort many plasma membrane receptors and transporters and control cellular signaling and metabolism. How the membrane fission events are catalyzed is poorly understood. Here, we identify the novel CROP complex as a factor acting at this step. CROP integrates PROPPIN Atg18 with a part of the endosome- and vacuole-associated retromer complex to generate a membrane fission device of much higher potency. We studied its activity in yeast, in human cells and on liposomes.
HostingRepository	PRIDE
AnnounceDate	2022-05-05
AnnouncementXML	Submission_2022-05-05_05:08:37.652.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Patrice Waridel
SpeciesList	scientific name: Saccharomyces cerevisiae (Baker's yeast); NCBI TaxID: 4932;
ModificationList	ubiquitinylated lysine; methylthiolated residue; phosphorylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Velos; Q Exactive; Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2022-01-25 07:32:53	ID requested
⏵ 1	2022-05-05 05:08:38	announced

Courtellemont T, De Leo MG, Gopaldass N, Mayer A, CROP: a retromer-PROPPIN complex mediating membrane fission in the endo-lysosomal system. EMBO J, 41(10):e109646(2022) [pubmed]

submitter keyword: yeast, endo-lysosomal system

Andreas Mayer
contact affiliation	Department of Biochemistry, University of Lausanne, Ch. des Boveresses 155, CH-1066 Epalinges
contact email	andreas.mayer@unil.ch
lab head
Patrice Waridel
contact affiliation	University of Lausanne
contact email	patrice.waridel@unil.ch
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD031244
     1. Label: PRIDE project
     2. Name: CROP: A Retromer- PROPPIN complex mediating membrane fission in the endo-lysosomal system