PXD031240
PXD031240 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | ITRAQ-based quantitative proteomics analysis of forest musk deer with pneumonia |
| Description | Pneumonia can seriously threaten the life of forest musk deer (an endangered species). To gain a comprehensive understanding of pneumonia pathogenesis in forest musk deer, iTRAQ-based proteomics analysis was performed in diseased (Phe group) and normal (Ctrl group) lung tissues of forest musk deer that died of pneumonia. Results showed that 355 proteins were differentially expressed (fold change ≥ 1.2 and Q < 0.05) in Phe vs Ctrl experiments. GO/KEGG annotation and enrichment analyses showed that dysregulated proteins might play vital roles in bacterial infection and immunity. Given the close association of bacterial infection and pneumonia, 32 dysregulated proteins related to Staphylococcus aureus infection, bacterial invasion of epithelial cells, and pathogenic Escherichia coli infection were screened out. Among these 32 proteins, 13 proteins were mapped to the bovine genome. Given the close phylogenetic relationships of forest musk deer and bovine, the protein-protein interaction networks of the above-ment |
| HostingRepository | iProX |
| AnnounceDate | 2022-10-23 |
| AnnouncementXML | Submission_2023-01-31_19:58:42.964.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Jie Tang |
| SpeciesList | scientific name: Moschus berezovskii; NCBI TaxID: 68408; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | TripleTOF 5600+ |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2022-01-25 05:25:29 | ID requested | |
| 1 | 2022-10-23 21:09:46 | announced | |
| ⏵ 2 | 2023-01-31 19:58:43 | announced | 2023-02-01: Update publication information. |
Publication List
| Tang J, Suo L, Li F, Yang C, Bian K, Wang Y, ITRAQ-based quantitative proteomics analysis of forest musk deer with pneumonia. Front Vet Sci, 9():1012276(2022) [pubmed] |
Keyword List
| submitter keyword: forest musk deer,pneumonia, iTRAQ, mass spectrometry, proteomics, bacterium, immunity |
Contact List
| Jie Tang | |
|---|---|
| contact affiliation | Shaanxi Institute of Zoology |
| contact email | yaya184@126.com |
| lab head | |
| Jie Tang | |
| contact affiliation | Shaanxi Institute of Zoology |
| contact email | yaya184@126.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
to receive all new ProteomeXchange dataset release announcements!
