PXD031223 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Chronic Aicar Treatment Identifies Sex-specific Phenotypes in the Aging Mouse Heart |
Description | Heart failure represents a leading cause of mortality in the elderly population. Although aging features include diastolic dysfunction and interstitial fibrosis in both males and females, it becomes increasingly apparent that aged male and female hearts are phenotypically different. There were fundamental differences in extracellular matrix (ECM) composition and architecture and heart function indices at the baseline, which were further accentuated by Aicar treatment. By combining in vivo, ex vivo, and in vitro strategies, we demonstrated that there are sex-specific features that influence the response to pharmacological intervention in the aging mouse heart. |
HostingRepository | PRIDE |
AnnounceDate | 2022-06-23 |
AnnouncementXML | Submission_2022-06-23_15:29:57.637.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Nelufa Islam |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | No PTMs are included in the dataset |
Instrument | Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-01-25 00:47:20 | ID requested | |
⏵ 1 | 2022-06-23 15:29:58 | announced | |
Publication List
Angelini A, Ortiz-Urbina J, Trial J, Reddy AK, Malovannaya A, Jain A, Entman ML, Taffet GE, Cieslik KA, Sex-specific phenotypes in the aging mouse heart and consequences for chronic fibrosis. Am J Physiol Heart Circ Physiol, 323(2):H285-H300(2022) [pubmed] |
Keyword List
submitter keyword: extracellular matrix, mouse, aging, heart, label-free profiling |
Contact List
Katarzyna A Cieslik |
contact affiliation | Associate Professor Department of Medicine-Cardiovascular Sciences Baylor College of Medicine Houston, TX USA |
contact email | cieslik@bcm.edu |
lab head | |
Nelufa Islam |
contact affiliation | Baylor College of Medicine |
contact email | nelufa.islam@bcm.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/06/PXD031223 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD031223
- Label: PRIDE project
- Name: Chronic Aicar Treatment Identifies Sex-specific Phenotypes in the Aging Mouse Heart