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PXD031223

PXD031223 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleChronic Aicar Treatment Identifies Sex-specific Phenotypes in the Aging Mouse Heart
DescriptionHeart failure represents a leading cause of mortality in the elderly population. Although aging features include diastolic dysfunction and interstitial fibrosis in both males and females, it becomes increasingly apparent that aged male and female hearts are phenotypically different. There were fundamental differences in extracellular matrix (ECM) composition and architecture and heart function indices at the baseline, which were further accentuated by Aicar treatment. By combining in vivo, ex vivo, and in vitro strategies, we demonstrated that there are sex-specific features that influence the response to pharmacological intervention in the aging mouse heart.
HostingRepositoryPRIDE
AnnounceDate2022-06-23
AnnouncementXMLSubmission_2022-06-23_15:29:57.637.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterNelufa Islam
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-01-25 00:47:20ID requested
12022-06-23 15:29:58announced
Publication List
Angelini A, Ortiz-Urbina J, Trial J, Reddy AK, Malovannaya A, Jain A, Entman ML, Taffet GE, Cieslik KA, Sex-specific phenotypes in the aging mouse heart and consequences for chronic fibrosis. Am J Physiol Heart Circ Physiol, 323(2):H285-H300(2022) [pubmed]
Keyword List
submitter keyword: extracellular matrix, mouse, aging, heart, label-free profiling
Contact List
Katarzyna A Cieslik
contact affiliationAssociate Professor Department of Medicine-Cardiovascular Sciences Baylor College of Medicine Houston, TX USA
contact emailcieslik@bcm.edu
lab head
Nelufa Islam
contact affiliationBaylor College of Medicine
contact emailnelufa.islam@bcm.edu
dataset submitter
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Dataset FTP location
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PRIDE project URI
Repository Record List
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