PXD031223

PXD031223 is an original dataset announced via ProteomeXchange.

Title	Chronic Aicar Treatment Identifies Sex-specific Phenotypes in the Aging Mouse Heart
Description	Heart failure represents a leading cause of mortality in the elderly population. Although aging features include diastolic dysfunction and interstitial fibrosis in both males and females, it becomes increasingly apparent that aged male and female hearts are phenotypically different. There were fundamental differences in extracellular matrix (ECM) composition and architecture and heart function indices at the baseline, which were further accentuated by Aicar treatment. By combining in vivo, ex vivo, and in vitro strategies, we demonstrated that there are sex-specific features that influence the response to pharmacological intervention in the aging mouse heart.
HostingRepository	PRIDE
AnnounceDate	2022-06-23
AnnouncementXML	Submission_2022-06-23_15:29:57.637.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Nelufa Islam
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2022-01-25 00:47:20	ID requested
⏵ 1	2022-06-23 15:29:58	announced

Angelini A, Ortiz-Urbina J, Trial J, Reddy AK, Malovannaya A, Jain A, Entman ML, Taffet GE, Cieslik KA, Sex-specific phenotypes in the aging mouse heart and consequences for chronic fibrosis. Am J Physiol Heart Circ Physiol, 323(2):H285-H300(2022) [pubmed]

submitter keyword: extracellular matrix, mouse, aging, heart, label-free profiling

Katarzyna A Cieslik
contact affiliation	Associate Professor Department of Medicine-Cardiovascular Sciences Baylor College of Medicine Houston, TX USA
contact email	cieslik@bcm.edu
lab head
Nelufa Islam
contact affiliation	Baylor College of Medicine
contact email	nelufa.islam@bcm.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/06/PXD031223

PRIDE project URI

• PRIDE
  1. PXD031223
     1. Label: PRIDE project
     2. Name: Chronic Aicar Treatment Identifies Sex-specific Phenotypes in the Aging Mouse Heart