PXD031219

PXD031219 is an original dataset announced via ProteomeXchange.

Title	Identification of early biomarkers in saliva in genetically engineered mouse model C(3)1-TAg of breast cancer
Description	Breast cancer is one of leading causes of death worldwide in the female population. Deaths from breast cancer could be reduced significantly through earlier and more efficient detection of the disease. Saliva, an oral fluid that contains an abundance of protein biomarkers, has been recognized as a promising diagnostic biofluid that is easy to isolate through non-invasive techniques. Assays on saliva can be performed rapidly and are cost-effective. Therefore, our work aimed to identify salivary biomarkers present in the initial stages of breast cancer, where cell alterations are not yet detectable by histopathological analysis. Using state-of-the-art techniques, we employed a transgenic mouse model of mammary cancer to identify molecular changes in precancerous stage breast cancer through protein analysis in saliva. Through corroborative molecular approaches, we established that proteins related to metabolic changes, inflammatory process and cell matrix degradation are detected in saliva at the onset of tumor development. Our work demonstrated that salivary protein profiles can be used to identify cellular changes associated with precancerous stage breast cancer through non-invasive means even prior to biopsy-evident disease.
HostingRepository	PRIDE
AnnounceDate	2022-08-12
AnnouncementXML	Submission_2022-08-12_00:00:53.727.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Isadora Sena
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2022-01-25 00:42:07	ID requested
⏵ 1	2022-08-12 00:00:54	announced

Gilson Sena IF, Fernandes LL, Lorandi LL, Santana TV, Cintra L, Lima IF, Iwai LK, Kramer JM, Birbrair A, Heller D, Identification of early biomarkers in saliva in genetically engineered mouse model C(3)1-TAg of breast cancer. Sci Rep, 12(1):11544(2022) [pubmed]

submitter keyword: breast cancer, saliva, biomarker, mammary tumor, proteins

Débora Heller
contact affiliation	Post Graduate Program in Dentistry, Cruzeiro do Sul University, SãoPaulo, Brazil; Hospital Israelita Albert Einstein, São Paulo, Brazil; Department of Oral Biology, School of Dental Medicine, The University of Buffalo, State University of New 17 York, Buffalo, NY, USA
contact email	debora.heller@cruzeirodosul.edu.br
lab head
Isadora Sena
contact affiliation	UFMG
contact email	isadorafgs@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/08/PXD031219

PRIDE project URI

• PRIDE
  1. PXD031219
     1. Label: PRIDE project
     2. Name: Identification of early biomarkers in saliva in genetically engineered mouse model C(3)1-TAg of breast cancer