PXD031214

PXD031214 is an original dataset announced via ProteomeXchange.

Title	Identification of a HTT-specific binding motif in DNAJB1 essential for suppression and disaggregation of HTT
Description	Identification of the binding interface between HttExon1Q48 and the molecular chaperone DNAJB1. The proteins were incubated and cross-linked in vitro and the binding interface was mapped to the hinge region between CTDI and CTDII of DNAJB1 and the proline rich domain of HTTEXon1Q48.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:17:40.820.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Heike Stephanowitz
SpeciesList	scientific name: Escherichia coli; NCBI TaxID: 562; scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2022-01-25 00:38:25	ID requested
1	2022-10-14 16:38:22	announced
⏵ 2	2023-11-14 08:17:41	announced	2023-11-14: Updated project metadata.

Ayala Mariscal SM, Pigazzini ML, Richter Y, Ö, zel M, Grothaus IL, Protze J, Ziege K, Kulke M, ElBediwi M, Vermaas JV, Colombi Ciacchi L, K, ö, ppen S, Liu F, Kirstein J, Identification of a HTT-specific binding motif in DNAJB1 essential for suppression and disaggregation of HTT. Nat Commun, 13(1):4692(2022) [pubmed]

submitter keyword: mass spectrometry, DNAJB1,HTT, crosslinking

Janine Kirstein
contact affiliation	Faculty of Chemistry and Biology University of Bremen
contact email	kirstein@uni-bremen.de
lab head
Heike Stephanowitz
contact affiliation	Leibniz-Forschungsinstitut für Molekulare Pharmakologie
contact email	stephanowitz@fmp-berlin.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/10/PXD031214

PRIDE project URI

• PRIDE
  1. PXD031214
     1. Label: PRIDE project
     2. Name: Identification of a HTT-specific binding motif in DNAJB1 essential for suppression and disaggregation of HTT